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The study sample included children near the 10\u2010year age cutoff for high\u2010risk disease (6.0\u201013.9 years at diagnosis) and without other high\u2010risk features (high white cell count, unfavorable cytogenetics). Children 10.0\u201013.9 years treated per high\u2010risk protocols did not have inferior outcomes compared with children aged 6.0\u20109.9 years initiating treatment per standard\u2010risk protocols. The study indicates that, in the era of cytogenetics, an age threshold of 10 years might not be an independent prognostic marker. Multicenter analyses are needed.<\/jats:p>","DOI":"10.1002\/pbc.30825","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T04:05:00Z","timestamp":1703563500000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Missing the mark? 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