{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:32:13Z","timestamp":1782448333042,"version":"3.54.5"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fetal and neonatal alloimmune thrombocytopenia (FNAIT) ensues from parental incompatibility for platelet alloantigens with maternal sensitization. HPA\u20101a\/1b incompatibility is the most common cause of FNAIT in Caucasians. Placental villitis and lower birthweight in FNAIT suggest anti\u2010HPA\u20101a may have effects beyond inducing thrombocytopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Does FNAIT secondary to anti\u2010HPA\u20101a result in smaller newborns and, the corollary, does antenatal management of FNAIT increase birthweight?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>Birthweights of 270 FNAIT\u2010affected newborns from a randomized clinical trial and a NAITbabies.org survey (135 paired siblings) were compared with those of published controls and treated to untreated FNAIT\u2010affected siblings. Birthweights were converted to percentiles to account for gestational age, sex, and role of birth order in birth weight. Body weights of FNAIT\u2010affected and \u2010unaffected pups in a mouse FNAIT model were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Untreated siblings in both the clinical trial and NAITbabies.org cohorts were not small, compared with normal controls. However, treated siblings in both cohorts had significantly higher birthweight percentiles compared with their previous untreated affected sibling. After accounting for gestational age, sex, and birth order, increased birthweight percentile in treated compared with the untreated siblings remained significant in both cohorts. FNAIT\u2010affected neonatal mice had lower bodyweights than FNAIT\u2010unaffected pups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Untreated FNAIT\u2010affected newborns were not small; however, treatment of FNAIT\u2010affected pregnancies increased newborn birthweights despite corrections to account for other factors that might have influenced the results. High dose IVIG is believed to \u201cblock\u201d FcRn and lower maternal anti\u2010HPA\u20101a levels, and thus increase birthweights by reducing levels of maternal anti\u2010HPA\u20101a and reducing placental villitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.30835","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T23:35:01Z","timestamp":1705016101000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Does anti\u2010HPA\u20101a affect birthweight in fetal and neonatal alloimmune thrombocytopenia?"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0833-243X","authenticated-orcid":false,"given":"Margaret","family":"McKelvy","sequence":"first","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srishti","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Norton College of Medicine SUNY Upstate Medical University Syracuse New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie Vander","family":"Haar","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine Department of Obstetrics and Gynecology Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhavi","family":"Lakkaraja","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Fred Hutchinson Cancer Center Department of Pediatrics University of Washington School of Medicine  Seattle USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Tomy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hurley Medical Center  Flint Michigan 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