{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:24Z","timestamp":1786978344499,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Opsoclonus\u2010myoclonus\u2010ataxia syndrome (OMAS) is an autoimmune central nervous system disorder, primarily manifesting as a paraneoplastic sequalae to neuroblastoma, and characterized by motor disorders and behavioral disturbances. OMAS is typified by aberrant B\u2010cell and T\u2010cell activation. Current treatment involves immunosuppression using corticosteroids, intravenous immunoglobulin, and rituximab. However, these approaches often lead to treatment\u2010related toxicities and symptomatic recurrences with chronic neurocognitive impairment. We treated three children with refractory neuroblastoma\u2010associated OMAS with tacrolimus, a T\u2010cell\u2010targeting calcineurin inhibitor, effectively controlling symptoms within a month and enabling the discontinuation of immunosuppression with minimal side effects. Tacrolimus shows promise as a therapeutic option for refractory OMAS.<\/jats:p>","DOI":"10.1002\/pbc.30903","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T03:47:33Z","timestamp":1707277653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Successful use of tacrolimus for treatment\u2010refractory neuroblastoma\u2010associated opsoclonus\u2010myoclonus\u2010ataxia syndrome: A case series"],"prefix":"10.1002","volume":"71","author":[{"given":"Sara","family":"Delap","sequence":"first","affiliation":[{"name":"Department of Hospital Pediatrics Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"Department of Pediatrics Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3766-3572","authenticated-orcid":false,"given":"Nilay","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ohio State University College of Medicine  Columbus Ohio USA"},{"name":"Division of Hematology\/Oncology\/BMT Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Kuns","sequence":"additional","affiliation":[{"name":"Center for Biobehavioral Health Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Franklin","sequence":"additional","affiliation":[{"name":"Center for Biobehavioral Health Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6786-8128","authenticated-orcid":false,"given":"Micah A.","family":"Skeens","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Ohio State University College of Medicine  Columbus Ohio USA"},{"name":"Division of Hematology\/Oncology\/BMT Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"Center for Biobehavioral Health Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001153"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738040190120201"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010\u20103114"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20125"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20104642(17)30130\u2010X"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2017.04.027"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2015.09.002"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2011.05.013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100037\u20101609038"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2022.08.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073808324217"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13015"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0887\u20108994(00)00227\u20107"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1043454204272560"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00468"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2022.101741"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2022.06.007"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272\u2010022\u201000512\u20103"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1996.03890280081011"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10427"},{"issue":"14","key":"e_1_2_7_22_1","first-page":"2693","article-title":"Effect of tacrolimus in idiopathic membranous nephropathy: a meta\u2010analysis","volume":"127","author":"Santosh T","year":"2014","journal-title":"Chin Med J (Engl)"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2012.595"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2018.02.009"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100029\u20101237723"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426\u2010200411000\u201000006"},{"key":"e_1_2_7_27_1","unstructured":"ArayaAA TasnifY.Tacrolimus. 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