{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:36:46Z","timestamp":1790786206932,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007560","name":"Chiesi Farmaceutici","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007560","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In pediatric transfusion\u2010dependent thalassemia (TDT) patients, we evaluated the prevalence, pattern, and clinical associations of pancreatic siderosis and the changes in pancreatic iron levels and their association with baseline and changes in total body iron balance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We considered 86 pediatric TDT patients consecutively enrolled in the Extension\u2010Myocardial Iron Overload in Thalassemia Network. Iron overload (IO) was quantified by R2* magnetic resonance imaging (MRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010three (73%) patients had pancreatic IO (R2*\u00a0&gt;\u00a038\u00a0Hz). Global pancreas R2* values were significantly correlated with mean serum ferritin levels, MRI liver iron concentration (LIC) values, and global heart R2* values. Global pancreas R2* values were significantly higher in patients with altered versus normal glucose metabolism. Thirty\u2010one patients also performed the follow\u2010up MRI at 18\u00a0\u00b1\u00a03\u00a0months. Higher pancreatic R2* values were detected at the follow\u2010up, but the difference versus the baseline MRI was not significant. The 20% of patients with baseline pancreatic IO showed no pancreatic IO at the follow\u2010up. The 46% of patients without baseline pancreatic IO developed pancreatic siderosis. The changes in global pancreas R2* between the two MRIs were not correlated with baseline serum ferritin levels, baseline, final, and changes in MRI LIC values, or baseline pancreatic iron levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In children with TDT, pancreatic siderosis is a frequent finding associated with hepatic siderosis and represents a risk factor for myocardial siderosis and alterations of glucose metabolism. Iron removal from the pancreas is exceptionally challenging and independent from hepatic iron status.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30923","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T15:09:41Z","timestamp":1708614581000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pancreatic iron in pediatric transfusion\u2010dependent beta\u2010thalassemia patients: A longitudinal MRI study"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2284-8585","authenticated-orcid":false,"given":"Antonella","family":"Meloni","sequence":"first","affiliation":[{"name":"Bioengineering Unit Fondazione G. Monasterio CNR\u2010Regione Toscana  Pisa Italy"},{"name":"Department of Radiology Fondazione G. Monasterio CNR\u2010Regione Toscana  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pistoia","sequence":"additional","affiliation":[{"name":"Department of Radiology Fondazione G. Monasterio CNR\u2010Regione Toscana  Pisa Italy"},{"name":"U.O.C. Ricerca Clinica Fondazione G. Monasterio CNR\u2010Regione Toscana  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Caterina","family":"Putti","sequence":"additional","affiliation":[{"name":"Dipartimento della Salute della Donna e del Bambino Clinica di Emato\u2010Oncologia Pediatrica Azienda Ospedaliero\u2010Universit\u00e0 di Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Longo","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Day Hospital della Talassemia e delle Emoglobinopatie Azienda Ospedaliero\u2010Universitaria \u201cS. Anna,\u201d  Cona Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Corigliano","sequence":"additional","affiliation":[{"name":"Ematologia Microcitemia Ospedale San Giovanni di Dio \u2010 ASP Crotone  Crotone Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Ricchi","sequence":"additional","affiliation":[{"name":"U.O.S.D. Malattie Rare del Globulo Rosso Azienda Ospedaliera di Rilievo Nazionale \u201cA. Cardarelli\u201d  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenza","family":"Rossi","sequence":"additional","affiliation":[{"name":"U.O.C. Ematologia Ospedale di Cosenza  Cosenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Casini","sequence":"additional","affiliation":[{"name":"SOC Oncologia, Ematologia e Trapianto di Cellule Staminali Emopoietiche Meyer Children's Hospital IRCCS  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Righi","sequence":"additional","affiliation":[{"name":"Diagnostica per Immagini e Radiologia Interventistica Ospedale del Delta  Lagosanto Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Renne","sequence":"additional","affiliation":[{"name":"Struttura Complessa di Cardioradiologia\u2010UTIC Presidio Ospedaliero \u201cGiovanni Paolo II,\u201d  Lamezia Terme Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Peritore","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa Complessa di Radiologia \u201cARNAS\u201d Civico Di Cristina Benfratelli  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Barbuto","sequence":"additional","affiliation":[{"name":"U.O.C. 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