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Median age was 18\u00a0years [range: 0\u201321]. High\u2010grade dysplasia was present in 67% of cases. Therapy consisted of primary surgery for all cases, regional lymph node dissection (LND) (74%), radiotherapy (71%), chemotherapy (8%), and chemoradiation (7%). The 5\u2010year OS rate was 93.2% [95% confidence interval (CI): 86.9%\u201399.9%], respectively. Patients who underwent associated LND had improved OS (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0083, log\u2010rank test) with a 5\u2010year OS at 82.4% [95% CI: 66.1%\u2013100%] versus 97.6% [95% CI: 93.0%\u2013100%]. A significant difference in OS was found with unfavorable outcomes after positive marginal status: 5\u2010year OS 84.1% [95% CI: 71.0%\u201399.7%] versus 100% [95% CI: 100%]; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001. Adjuvant therapy did not seem to impact the outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study confirms that AdCC in children and young adults has an overall good prognosis despite frequent high grade. It suggests that cervical LND may be of importance, but the value of systematic adjuvant therapy is not confirmed. These findings emphasize the importance and relevance of population\u2010based studies in shaping clinical practice and informing the design of future prospective investigations.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.30928","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T04:14:21Z","timestamp":1709180061000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Adenoid cystic carcinoma of the parotid and submandibular glands in children and young adults: A population\u2010based study"],"prefix":"10.1002","volume":"71","author":[{"given":"Alisa L.","family":"Phillips","sequence":"first","affiliation":[{"name":"University of Tennessee Health Science Center College of Medicine  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Sheyn","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Tennessee Health Science Center College of Medicine  Memphis Tennessee USA"},{"name":"Division of Pediatric Otolaryngology Le Bonheur Children's Hospital  Memphis Tennessee USA"},{"name":"Division of Pediatric Otolaryngology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey C.","family":"Rastatter","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology \u2010 Head and Neck Surgery Ann &amp; Robert H. 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