{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T16:53:02Z","timestamp":1772902382366,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010733","name":"B\u00f8rnecancerfonden","doi-asserted-by":"publisher","award":["2018\u20103682"],"award-info":[{"award-number":["2018\u20103682"]}],"id":[{"id":"10.13039\/100010733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010733","name":"B\u00f8rnecancerfonden","doi-asserted-by":"publisher","award":["2020\u20106755"],"award-info":[{"award-number":["2020\u20106755"]}],"id":[{"id":"10.13039\/100010733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018820","name":"Farmer of Oelufgaard Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018820","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010351","name":"Grosserer M. Brogaard og Hustrus Mindefond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010351","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The treatment of acute lymphoblastic leukemia (ALL) is frequently complicated by toxicity, including venous thromboembolism (VTE) affecting roughly 8% of patients. VTE can lead to post\u2010thrombotic syndrome (PTS), a group of signs and symptoms developed as a complication to deep venous thrombosis (DVT), imposing risk of permanent disability and reduced quality of life (QoL). PTS prevalence ranges from 0% to 70%, reflecting very heterogenous cohorts and assessment tools. We aimed to estimate sequelae, including PTS and QoL in children and adults (&lt;45\u00a0years old) who had a DVT during ALL treatment. PTS and QoL scores were obtained through use of Villalta and Modified Villalta Scale, PedsQL, and Short Form\u201036 questionnaires. The cohort comprised 20 children (&lt;18\u00a0years) and seven adults (median age: 12.9\u00a0years, range: 2\u201344\u00a0years) at the time of DVT diagnosis. In total, 25 ALL survivors underwent PTS examination. The examination took place when survivors were 7\u201348\u00a0years (median age: 20.3\u00a0years, median follow\u2010up time 6.8\u00a0years). QoL was assessed correlating cases with three matching ALL survivors without VTE. Two adults (15.4%) showed mild or moderate PTS. Eight children (66.7%) were diagnosed with mild PTS, while three cases had collaterals as sole symptoms. Pain or symptoms affecting daily life were reported by 16%. No difference in QoL was found (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.9). This study underscores the need for comprehensive population\u2010based investigations with validation of PTS instruments in ALL survivors.<\/jats:p>","DOI":"10.1002\/pbc.30937","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:20:41Z","timestamp":1710375641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sequelae and post\u2010thrombotic syndrome after venous thromboembolism in acute lymphoblastic leukemia survivors treated on the NOPHO ALL2008 protocol"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8857-8629","authenticated-orcid":false,"given":"Merete","family":"Dam","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Aarhus University Hospital, and Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Line Stensig","family":"Lynggaard","sequence":"additional","affiliation":[{"name":"Department of Hematology, Aarhus University Hospital, and Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d3lafur G.","family":"J\u00f3nsson","sequence":"additional","affiliation":[{"name":"National University Hospital of Iceland  Reykjavik Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonata","family":"Saulyte Trakymiene","sequence":"additional","affiliation":[{"name":"Clinic of Children's Diseases, Faculty of Medicine Vilnius University, Hospital Santaros Klinikos  Vilnius Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrin","family":"Palk","sequence":"additional","affiliation":[{"name":"The North Estonia Medical Centre  Tallinn Estonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Jarvis","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology and Oncology Oslo University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liv","family":"Andr\u00e9s\u2010Jensen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruta","family":"Tuckuviene","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Rigshospitalet Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3902-3694","authenticated-orcid":false,"given":"Birgitte Klug","family":"Albertsen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine, Aarhus University Hospital, and Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2014.59.1636"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(08)60457\u20102"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.9548.1"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2352\u20103026(19)30050\u2010x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(13)70351\u20106"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf02592556"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0049\u20103848(01)00286\u20109"},{"issue":"2","key":"e_1_2_11_9_1","first-page":"120","article-title":"Effect of disease and chemotherapy on hemostasis in children with acute lymphoid leukemia","volume":"16","author":"Mitchell LG","year":"1994","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102007\u20101000660"},{"issue":"2","key":"e_1_2_11_11_1","first-page":"330","article-title":"L\u2010Asparaginase and the effect of age on coagulation and fibrinolysis in childhood acute lymphoblastic leukemia","volume":"100","author":"Appel IM","year":"2008","journal-title":"Thromb Haemost"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010021\u201001383\u20102"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538\u20107836.2010.04034.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201001\u2010827949"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100039\u20101688412"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20230"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538\u20107836.2005.01467.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.828702"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13236"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000130"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation\u20102016.1.413"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2015.08.005"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010023\u201003651\u20106"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2016_126"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.026989"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24840"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538\u20107836.2008.02901.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2003.09.008"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2007.12.006"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.123455"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14984"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102009\u201007\u2010199174"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102020\u2010045543"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(16)30035\u20103"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2022.100032"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126268"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.10.064"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102006\u201012\u2010061234"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650\u2010199303000\u201000006"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25302"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2023.01.004"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20101738\u20101313"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.06.076"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2016.1230012"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e32834bdb1c"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2005.09.033"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.07.003"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538\u20107836.2011.04594.x"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1177\/0268355516686597"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.20452\/pamw.2353"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538\u20107836.2009.03294.x"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u2010125\u20101\u2010199607010\u201000001"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/mph.0000000000000399"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.12.005"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29581"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432\u2010023\u201005475\u20107"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000029367"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.30937","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T13:07:30Z","timestamp":1753448850000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.30937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,13]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/pbc.30937"],"URL":"https:\/\/doi.org\/10.1002\/pbc.30937","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,13]]},"assertion":[{"value":"2023-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e30937"}}