{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:56Z","timestamp":1786978436666,"version":"build-2736575974"},"reference-count":62,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003107","name":"Bundesministerium f\u00fcr Gesundheit","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003107","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tumors of the central nervous system (CNS) are the second most common type of pediatric cancer in Germany. We aimed to describe registration practice, incidence, and survival patterns for childhood CNS tumors in Germany for the past 40\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>Including all CNS tumor cases in children diagnosed at ages 0\u201314\u00a0years registered at the German Childhood Cancer Registry (GCCR) in 1980\u20132019 (for survival analysis 1980\u20132016), we calculated age\u2010specific and age\u2010standardized incidence rates (ASIR) over time, average annual percentage changes (AAPC), and 1\u2010 and 5\u2010year overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>While we observed a pronounced increase in ASIR after the establishment of the GCCR during the 1980s, ASIR for all pediatric CNS tumors combined continued to increase markedly from 28.6 per million in 1990\u20131999 to 43.3 in 2010\u20132019 (AAPC\u00a0=\u00a02.7% in 1991\u20132010, AAPC\u00a0=\u00a00.3% in 2010\u20132019). The 5\u2010year overall survival from CNS tumors improved from 63% in the 1980s, 70% in the 1990s to 79% in 2010\u20132016. These improvements have occurred across all age groups. Children diagnosed with ependymomas and choroid plexus tumors experienced the strongest increase (from 54% to 81%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Observed increases in incidence rates for pediatric CNS tumors are likely only partially caused by actual increasing case numbers. The majority is a function of improved registration and, to a minor extent, improvements in diagnostics. Survival from pediatric CNS tumors has, by and large, improved consistently, leading to a growing population of childhood cancer survivors with diverse health biographies and risk of lifelong adverse impact on health and wellbeing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.30954","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:19:41Z","timestamp":1711498781000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Registration, incidence patterns, and survival trends of central nervous system tumors among children in Germany 1980\u20132019: An analysis of 40\u00a0years based on data from the German Childhood Cancer Registry"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5885-7002","authenticated-orcid":false,"given":"Maike","family":"Wellbrock","sequence":"first","affiliation":[{"name":"Research Group Aetiology and Inequalities in Childhood Cancer Division of Childhood Cancer Epidemiology Institute of Medical Biostatistics Epidemiology and Informatics (IMBEI) University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"},{"name":"Department of Prevention and Evaluation Leibniz Institute for Prevention Research and Epidemiology \u2010 BIPS  Bremen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Voigt","sequence":"additional","affiliation":[{"name":"German Childhood Cancer Registry\/Division of Childhood Cancer Epidemiology Institute of Medical Biostatistics Epidemiology and Informatics (IMBEI) University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecile","family":"Ronckers","sequence":"additional","affiliation":[{"name":"German Childhood Cancer Registry\/Division of Childhood Cancer Epidemiology Institute of Medical Biostatistics Epidemiology and Informatics (IMBEI) University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree","family":"Grabow","sequence":"additional","affiliation":[{"name":"German Childhood Cancer Registry\/Division of Childhood Cancer Epidemiology Institute of Medical Biostatistics Epidemiology and Informatics (IMBEI) University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Spix","sequence":"additional","affiliation":[{"name":"German Childhood Cancer Registry\/Division of Childhood Cancer Epidemiology Institute of Medical Biostatistics Epidemiology and Informatics (IMBEI) University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9982-3300","authenticated-orcid":false,"given":"Friederike","family":"Erdmann","sequence":"additional","affiliation":[{"name":"Research Group Aetiology and Inequalities in Childhood Cancer Division of Childhood Cancer Epidemiology Institute of Medical Biostatistics Epidemiology and Informatics (IMBEI) University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"},{"name":"Department of Prevention and Evaluation Leibniz Institute for Prevention Research and Epidemiology \u2010 BIPS  Bremen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,26]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Steliarova\u2010FoucherE ColombetM RiesL et\u00a0al.International Incidence Of Childhood Cancer volume III (electronic version).IARC. 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