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We compared the coagulation profile of children with SCT, different sickle cell disease (SCD) genotypes, and healthy controls. Compared to controls and similarly to HbSC patients, 41 SCT children (mean age 6.85\u00a0years; 20 males; 88% Africans) had a characteristic procoagulant profile: higher levels of factor VIII, von Willebrand factor (VWF) Ag and CBA, D\u2010dimer; lower levels of ADAMTS 13 activity, ADAMTS13 activity: VWFAg, plasminogen activator inhibitor, tissue plasminogen activator. Moreover, 13\/41 had clinical complications of SCD, five requiring hospitalization.<\/jats:p>","DOI":"10.1002\/pbc.30971","type":"journal-article","created":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T03:38:30Z","timestamp":1711769910000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early\u2010onset indicators of a hypercoagulable state and clinical complications in a cohort of children with sickle cell trait"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9479-6366","authenticated-orcid":false,"given":"Giulia","family":"Reggiani","sequence":"first","affiliation":[{"name":"Department of Women's and Child's Health Pediatric Hematology\u2010Oncology Unit Azienda Ospedaliera\u2010Universit\u00e0 di Padova  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Paola","family":"Boaro","sequence":"additional","affiliation":[{"name":"Department 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