{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:24Z","timestamp":1786978344470,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T00:00:00Z","timestamp":1712793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST 111\u20102314\u2010B\u2010002\u2010213\u2010MY3"],"award-info":[{"award-number":["MOST 111\u20102314\u2010B\u2010002\u2010213\u2010MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["111\u2010UN0018"],"award-info":[{"award-number":["111\u2010UN0018"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neuroblastoma varies widely in risk. Risk indicators in infants with incidental neuroblastoma refine treatment confidence for observation or intervention. The potential of functional imaging, particularly PET\/CT, remains to be defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>\n                      A retrospective review of infants under 18\u00a0months diagnosed with incidental neuroblastoma from 2008 to May 2022 in our institute was conducted. Before October 2015, incidental patients were treated similarly to symptomatic cases, undergoing biopsy or surgical excision upon diagnosis (early cohort). Post October 2015 (late cohort), treatment decisions were guided by PET\/CT findings, with\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010DOPA PET\/CT confirming diagnosis and staging. For tumors with low\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG uptake, an expectant observation approach was considered. Patient characteristics, diagnostic methods, image findings at diagnosis, treatment courses, and responses were compared between cohorts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty infants less than 18\u00a0months were identified with incidental neuroblastoma and completed PET\/CT at diagnosis. The early and late cohorts each comprised 15 patients. In the late cohort, nine out of 15 patients (60%) presented with localized FDG non\u2010avid tumors were offered the option of expectant observation. Of these, seven patients opted for observation, thereby avoiding surgery. Treatment outcomes were comparable between early and late cohorts, except for one mortality of a patient who, despite showing\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG activity, declined treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This study demonstrates the potential utility of\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010DOPA and\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET\/CT scans in aiding clinical decision\u2010making for infants with localized, incidental neuroblastoma. Given the concerns regarding radiation exposure, such imaging may be valuable for cases with suspected metastasis, initial large tumor size, or growth during follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.30983","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T01:24:10Z","timestamp":1712885050000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Feasibility of\n                    <sup>18<\/sup>\n                    F\u2010DOPA and\n                    <sup>18<\/sup>\n                    F\u2010FDG PET\/CT for guiding decision\u2010making for localized incidental neuroblastoma in infants under 18\u00a0months of age"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1661-0124","authenticated-orcid":false,"given":"Wan\u2010Ting","family":"Hung","sequence":"first","affiliation":[{"name":"Department of Surgery National Taiwan University Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine College of Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Ju","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen\u2010Lin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics School of Medicine College of Medicine Taipei Medical University and Taipei Medical University Hospital  Taipei Taiwan"},{"name":"Department of Pediatrics National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan\u2010Yin","family":"Ko","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"Department of Nuclear Medicine National Taiwan University Cancer Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4562-6002","authenticated-orcid":false,"given":"Shu\u2010Wei","family":"Chou","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"Department of Pediatrics National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiu\u2010Hao","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National Taiwan University Hospital  Taipei 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