{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:33:30Z","timestamp":1773419610715,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Nasopharyngeal carcinoma (NPC) is a rare pediatric cancer. Most children are first diagnosed with advanced locoregional disease. Identification of patients at higher risk of treatment failure is crucial as they may benefit from more aggressive initial treatment approaches.\n                      <jats:sup>18<\/jats:sup>\n                      Fluorine\u2010labeled fluoro\u20102\u2010deoxyglucose positron emission tomography (\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET) has shown promise as a prognostic tool for predicting outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Retrospective study of pediatric patients with locally advanced undifferentiated NPC who underwent\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010FDG PET\/CT prior to intial treatment. Predictive significance of metabolic PET parameters on survival outcomes were estimated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010two children were included, age range was 7.1\u201318\u00a0years at the time of diagnosis. The median follow\u2010up duration was 46.1\u00a0months. Three patients (9.4%) were classified as AJCC stage IIb, 13 patients (40.6%) as stage IIIa, eight patients (25%) as stage IIIb, and eight patients (25%) as stage IVa. Our findings revealed that high whole\u2010body metabolic tumor volume at the threshold of hepatic reference SUV\n                      <jats:sub>mean<\/jats:sub>\n                      (WB\u2010MTV\u2010HR) (&gt;135\u00a0mL) was associated with significantly lower event\u2010free survival (EFS) compared to the low WB\u2010MTV\u2010HR group (\u2264135\u00a0mL) (3\u2010year EFS: 50%\u00a0\u00b1\u00a018% vs. 82%\u00a0\u00b1\u00a08%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.015). Additionally, the 3\u2010year overall survival (OS) rates differed significantly between the high whole\u2010body metabolic tumor volume at the threshold of an SUV of 2.5 isocontour (WB\u2010MTV\u20102.5) group (MTV &gt;74\u00a0mL) and the low WB\u2010MTV\u20102.5 group (MTV \u226474\u00a0mL) (63%\u00a0\u00b1\u00a018% vs. 100%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.021).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study suggests that WB\u2010MTV parameters could serve as significant prognostic factors for disease progression in pediatric patients with locally advanced undifferentiated NPC. However, further prospective studies with larger sample sizes are needed to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.30998","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:43:30Z","timestamp":1713833010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictive significance of pretreatment\n                    <sup>18<\/sup>\n                    F\u2010FDG PET volumetric parameters on survival outcomes in pediatric patients with locally advanced undifferentiated nasopharyngeal carcinoma"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0902-7237","authenticated-orcid":false,"given":"Gihan","family":"El\u2010Hennawy","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine and Radiation Oncology National Cancer Institute (NCI) Cairo University  Cairo Egypt"},{"name":"Department of Nuclear Medicine Children Cancer Hospital Egypt (CCHE\u201057357)  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6769-7728","authenticated-orcid":false,"given":"Salma","family":"ElMenawi","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Children Cancer Hospital Egypt (CCHE\u201057357)  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman","family":"Nasr Said","sequence":"additional","affiliation":[{"name":"Department of Diagnostic &amp; Interventional Radiology National Cancer Institute (NCI) Cairo University  Cairo Egypt"},{"name":"Department of Radiodiagnosis Children Cancer Hospital Egypt (CCHE\u201057357)  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1562-9456","authenticated-orcid":false,"given":"Wael","family":"Zekri","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology National Cancer Institute (NCI) Cairo University  Cairo Egypt"},{"name":"Department of Pediatric Oncology Children Cancer Hospital Egypt (CCHE\u201057357)  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Zaghloul","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Radiation Oncology National Cancer Institute (NCI) Cairo University  Cairo Egypt"},{"name":"Department of Radiotherapy Children Cancer Hospital Egypt (CCHE\u201057357)  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Mustafa Abd","family":"Elsalam","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology National Cancer Institute (NCI) Cairo University  Cairo Egypt"},{"name":"Department of Pediatric Oncology Children Cancer Hospital Egypt (CCHE\u201057357)  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Habiba","family":"El\u2010Fendy","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cancer Institute (NCI) Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Elantably","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Radiation Oncology National Cancer Institute (NCI) Cairo University  Cairo Egypt"},{"name":"Department of Nuclear Medicine Children Cancer Hospital Egypt (CCHE\u201057357)  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001054"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20190107"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432\u2010017\u20102401\u2010y"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)00956-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40618-3"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2012.01.004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21372"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-019-01461-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00055-0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22521"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20823"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21258"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27395"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26528"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25376"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.01.009"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.111.090696"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2015.8.2.142"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01276"},{"key":"e_1_2_8_21_1","first-page":"1538","article-title":"Application of 18F\u2010FDG PET\/CT scan in following\u2010up of nasopharyngeal carcinoma after radiotherapy","volume":"23","author":"Yu DF","year":"2004","journal-title":"Ai Zheng"},{"key":"e_1_2_8_22_1","first-page":"159","article-title":"Clinical value of 18F\u2010fluoro\u20102\u2010deoxy\u2010D\u2010glucose positron emission tomography in detecting recurrent nasopharyngeal carcinoma at the parapharyngeal space after radiotherapy","volume":"23","author":"Wu DH","year":"2003","journal-title":"Di Yi Jun Yi Da Xue Xue Bao"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010012\u20102091\u20102"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13934"},{"key":"e_1_2_8_25_1","unstructured":"KassambaraA KosinskiM BiecekP.survminer: Drawing survival curves using 'ggplot2'. R package version 0.4.9.R Project;2021. Accessed April 14 2024.https:\/\/CRAN.R\u2010project.org\/package=survminer"},{"key":"e_1_2_8_26_1","unstructured":"HothornT.maxstat: Maximally selected rank statistics. R package version 0.7\u201025.R Project;2017. Accessed April 14 2024.https:\/\/CRAN.R\u2010project.org\/package=maxstat"},{"key":"e_1_2_8_27_1","volume-title":"Sample Size Tables for Clinical Studies","author":"Machin D","year":"1997"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.131847"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.116053"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.07.016"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-014-0268-5"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2015.275"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21363"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims\u201020\u201035"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.03.010"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2008.01.009"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNM.0b013e3283495662"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp430"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.4172\/2155-9619.1000166"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7253"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199001000-00010"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2015.11.024"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.30998","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pbc.30998","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.30998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:23:38Z","timestamp":1773411818000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.30998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,22]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/pbc.30998"],"URL":"https:\/\/doi.org\/10.1002\/pbc.30998","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,22]]},"assertion":[{"value":"2023-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e30998"}}