{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:01:48Z","timestamp":1778497308293,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T00:00:00Z","timestamp":1713052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T00:00:00Z","timestamp":1713052800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Myeloid neoplasms account for 50% of cases of pediatric leukemias in infants. Approximately 25%\u201350% of patients with newborn leukemia have cutaneous extramedullary disease (EMD). In less than 10% of patients, aleukemic leukemia cutis or isolated extramedullary disease with cutaneous involvement (cEMD) occurs when skin lesions appear prior to bone marrow involvement and systemic symptoms. Interestingly, in acute myeloid leukemia with cutaneous EMD (AML\u2010cEMD) and cEMD, spontaneous remissions have been reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>This is a multicentric retrospective cohort study aiming to describe characteristics, treatment, and outcome of infants with either cEMD or presence of cutaneous disease with involvement of the bone marrow (AML\u2010cEMD). This study included patients born between 1990 and 2018 from Italy, the Netherlands, Switzerland, and the United States, diagnosed between 0 and 6\u00a0months of life with cEMD or AML\u2010cEMD. Descriptive statistics, Fisher's exact test, Kaplan\u2013Meier method, and log rank test were applied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort consisted of\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a050 patients, including 42 AML\u2010cEMD and eight cEMD patients. The most common genetic mutation found was a\n                      <jats:italic>KMT2A<\/jats:italic>\n                      rearrangement (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a026, 52%). Overall 5\u2010year event\u2010free survival (EFS) and overall survival (OS) were 66% [confidence interval (CI): 51\u201378] and 75% [CI: 60\u201385], respectively. In two patients, complete spontaneous remission occurred without any therapy. Central nervous system (CNS) involvement was found in 25% of cEMD patients. No difference in outcomes was observed between the AML\u2010cEMD and cEMD groups, but none of the latter patients included in the study died.\n                      <jats:italic>KMT2A<\/jats:italic>\n                      rearrangements were not associated with poorer prognosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the largest cohort to date, our study describes the characteristics of infants with cutaneous involvement of myeloid neoplasms including cytomolecular findings and survival rates. Further prospective biologic and clinical studies of these infants with myeloid neoplasms will be required to individualize therapy for this rare patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.31006","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:44:04Z","timestamp":1713141844000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Characteristics and treatment of acute myeloid neoplasms with cutaneous involvement in infants up to 6\u00a0months of age: A retrospective study"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1422-3781","authenticated-orcid":false,"given":"Juliette","family":"Renaud","sequence":"first","affiliation":[{"name":"Pediatric Hematology\u2010Oncology Unit, Division of Pediatrics, Department Woman\u2010Mother\u2010Child Lausanne University Hospital (CHUV) and University of Lausanne 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