{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:49:55Z","timestamp":1785440995688,"version":"3.56.0"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T00:00:00Z","timestamp":1713657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T00:00:00Z","timestamp":1713657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sickle cell disease (SCD) is the commonest inherited blood disorder leading to complications occurring due to vaso\u2010occlusion including sight\u2010threatening retinopathy. Retinopathy can be managed if diagnosed early and vision loss can be prevented. Since, very less data are available from India, hence, this study was conducted in children (7\u201318 years) with SCD to diagnose retinopathy by using ocular coherence tomography (OCT) in subclinical stages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross sectional single\u2010center study was performed in 7\u201318 years age group children with SCD without any visual symptoms. Enrolled participants underwent complete ophthalmological examination including macula and optic disc thickness measurements using Cirrus HD\u2010OCT and results were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 55 participants, none had visual impairment. Significant fundoscopy finding (nonproliferative sickle cell retinopathy\/NPSR) was found in three patients (5.4%), thinning of central macula in four patients (7.27%), inner macula thinning in eight patients (14.5%), outer macula thinning in one patient (1.81%), retinal nerve fiber layer thinning in five patients (9%), ganglion cell layer to inner plexiform layer thinning in eight patients (14.54%). Overall NPSR was found in 5.4% patients detected with fundoscopy, whereas retinal layer thinning was found in 14 patients (25.4%) using OCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite of the significant prevalence of SCR, it is still underdiagnosed complication, leading to thinning of the retina from early ages; thus, its early diagnosis by regular screening using newer diagnostic methods can prevent progression to sight\u2010threatening complications and provide better quality of life for these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.31021","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T01:23:50Z","timestamp":1713749030000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early diagnosis of sickle cell retinopathy by using ocular coherence tomography in pediatric population (7\u201318 years) in central India"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4651-4078","authenticated-orcid":false,"given":"Pooja","family":"Soni","sequence":"first","affiliation":[{"name":"Department of Pediatrics All India Institute of Medical Sciences (AIIMS)  Bhopal Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavna","family":"Dhingra","sequence":"additional","affiliation":[{"name":"Department of Pediatrics All India Institute of Medical Sciences (AIIMS)  Bhopal Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samendra","family":"Karkhur","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology All India Institute of Medical Sciences (AIIMS)  Bhopal Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narendra K.","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Pediatrics All India Institute of Medical Sciences (AIIMS)  Bhopal Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijit P.","family":"Pakhare","sequence":"additional","affiliation":[{"name":"Department of Community and Family Medicine All India Institute of Medical Sciences (AIIMS)  Bhopal Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(04)17192\u20104"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971\u20105916.159492"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000423"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002321"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol\u20102018\u2010312305"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol\u20102019\u2010314567"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.08.010"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3129\/i08\u2010003"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2019.02.023"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_869_16"},{"key":"e_1_2_9_12_1","volume-title":"Diseases of the eye and adnexa, international statistical classification of diseases and related health problems","author":"World Health Organization (WHO)","year":"2007"},{"key":"e_1_2_9_13_1","first-page":"348p","volume-title":"A Systemic Approach","author":"Kanski JJ","year":"2019"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/jovr.jovr_51_17"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.17554\/j.issn.2409-5680.2017.03.52"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12886\u2010022\u201002321\u20101"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.17511\/ijpr.2016.2.03"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.72.10.727"},{"key":"e_1_2_9_19_1","volume-title":"Evidence\u2010Based Management of Sickle Cell Disease: Expert Panel Report","author":"National Heart, Lung, and Blood Institute","year":"2014"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15617"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2010.11.014"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/trt008"},{"key":"e_1_2_9_23_1","unstructured":"KhanM GawaiD TaurSBhagwatVR.Ocular Manifestations of sickle cell hemoglobinopathy: A study in tertiary eye care centre of North Maharashtra (India). Walawalkar International Medical Journal2019;6(1):11\u201025.http:\/\/www.wimjournal.com."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102016\u2010216124"},{"issue":"8","key":"e_1_2_9_25_1","first-page":"4747","article-title":"Therapeutic potential of Crizanlizumab (anti\u2010P\u2010selectin) in improving sickle cell retinopathy in mice","volume":"64","author":"Jadeja R","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.31021","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pbc.31021","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.31021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T14:22:49Z","timestamp":1773411769000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.31021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,21]]},"references-count":24,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1002\/pbc.31021"],"URL":"https:\/\/doi.org\/10.1002\/pbc.31021","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,21]]},"assertion":[{"value":"2023-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e31021"}}