{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:06:59Z","timestamp":1773493619120,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Childhood spinal tumors often present with musculoskeletal symptoms, potentially causing a misdiagnosis and delays in diagnosis and treatment. This study aims to identify, characterize, and compare children with spinal tumors who had prior musculoskeletal misdiagnoses to those without, analyzing clinical presentation, diagnostic interval, and outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>This retrospective cohort study evaluated all children aged 0\u201314\u00a0years diagnosed with a spinal tumor in Denmark from 1996 to 2018. The cohort was identified through the Danish Childhood Cancer Registry, and the registry data were supplemented with data from medical records. The survival was compared using the Kaplan\u2013Meier method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 58 patients, 57% (33\/58) received musculoskeletal misdiagnoses before the spinal tumor diagnosis. Misdiagnoses were mostly nonspecific (64%, 21\/33), involving pain and accidental lesions, while 36% (12\/33) were rheumatologic diagnoses. The patients with prior misdiagnosis had less aggressive tumors, fewer neurological\/general symptoms, and 5.5\u00a0months median diagnostic interval versus 3\u00a0months for those without a misdiagnosis. Those with prior misdiagnoses tended to have a higher 5\u2010year survival of 83% (95% confidence interval [CI]: 63%\u201392%) compared to 66% (95% CI: 44%\u201382%) for those without (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.15).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Less aggressive spinal tumors may manifest as gradual skeletal abnormalities and musculoskeletal symptoms without neurological\/general symptoms, leading to misdiagnoses and delays.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.31024","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T03:28:32Z","timestamp":1714966112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Musculoskeletal misdiagnoses in pediatric patients with spinal tumors"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8193-4360","authenticated-orcid":false,"given":"Aurora","family":"Dybedokken","sequence":"first","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene","family":"Mathiesen","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Hasle","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troels","family":"Herlin","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Thude","family":"Callesen","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren Holm","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Hallundb\u00e6k","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5498-3087","authenticated-orcid":false,"given":"Jesper","family":"Amstrup","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1094-6575","authenticated-orcid":false,"given":"S\u00f8ren","family":"Hagstr\u00f8m","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ninna","family":"Brix","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Aalborg University Hospital  Aalborg 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