{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T07:14:39Z","timestamp":1783581279325,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T00:00:00Z","timestamp":1714262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T00:00:00Z","timestamp":1714262400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R38 CA245095"],"award-info":[{"award-number":["R38 CA245095"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood & Cancer"],"published-print":{"date-parts":[[2024,7]]},"abstract":"Abstract<\/jats:title>\n \n Purpose<\/jats:title>\n Our objectives were to compare overall survival (OS) and pulmonary relapse between patients with metastatic Ewing sarcoma (EWS) at diagnosis who achieve rapid complete response (RCR) and those with residual pulmonary nodules after induction chemotherapy (non\u2010RCR).<\/jats:p>\n <\/jats:sec>\n \n Patients and methods<\/jats:title>\n This retrospective cohort study included children under 20\u00a0years with metastatic EWS treated from 2007 to 2020 at 19 institutions in the Pediatric Surgical Oncology Research Collaborative. Chi\u2010square tests were conducted for differences among groups. Kaplan\u2013Meier curves were generated for OS and pulmonary relapse.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among 148 patients with metastatic EWS at diagnosis, 61 (41.2%) achieved RCR. Five\u2010year OS was 71.2% for patients who achieved RCR, and 50.2% for those without RCR (\n p<\/jats:italic>\n \u00a0=\u00a0.04), and in multivariable regression among patients with isolated pulmonary metastases, RCR (hazards ratio [HR] 0.42; 95% confidence interval [CI]: 0.17\u20130.99) and whole lung irradiation (WLI) (HR 0.35; 95% CI: 0.16\u20130.77) were associated with improved survival. Pulmonary relapse occurred in 57 (37%) patients, including 18 (29%) in the RCR and 36 (41%) in the non\u2010RCR groups (\n p<\/jats:italic>\n \u00a0=\u00a0.14). Five\u2010year pulmonary relapse rates did not significantly differ based on RCR (33.0%) versus non\u2010RCR (47.0%,\n p<\/jats:italic>\n \u00a0=\u00a0.13), or WLI (38.8%) versus no WLI (46.0%,\n p<\/jats:italic>\n \u00a0=\u00a0.32).\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n Patients with EWS who had isolated pulmonary metastases at diagnosis had improved OS if they achieved RCR and received WLI, despite having no significant differences in rates of pulmonary relapse.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/pbc.31026","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:34:41Z","timestamp":1714350881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Survival outcomes in pediatric patients with metastatic Ewing sarcoma who achieve a rapid complete response of pulmonary metastases"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9530-2233","authenticated-orcid":false,"given":"Audra J.","family":"Reiter","sequence":"first","affiliation":[{"name":"Division of Pediatric Surgery Department of Surgery Northwestern University Feinberg School of Medicine, Ann and Robert H. Lurie Children's Hospital of Chicago Chicago Illinois USA"},{"name":"Northwestern Quality Improvement Research, and Education in Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Huang","sequence":"additional","affiliation":[{"name":"Northwestern Quality Improvement Research, and Education in Surgery Northwestern University Feinberg School of Medicine Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T.","family":"Craig","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery Department of Surgery Medical College of Wisconsin Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Davidoff","sequence":"additional","affiliation":[{"name":"Department of Surgery St. Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay J.","family":"Talbot","sequence":"additional","affiliation":[{"name":"Department of Surgery St. Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Coggins","sequence":"additional","affiliation":[{"name":"Department of Surgery St. Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Surgery St. Jude Children's Research Hospital Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6547-1220","authenticated-orcid":false,"given":"Jennifer H.","family":"Aldrink","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery Department of Surgery Nationwide Children's Hospital, The Ohio State University College of Medicine Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9835-3933","authenticated-orcid":false,"given":"Katherine C.","family":"Bergus","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery Department of Surgery Nationwide Children's Hospital, The Ohio State University College of Medicine Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6627-781X","authenticated-orcid":false,"given":"Taleen A.","family":"MacArthur","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie F.","family":"Polites","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery Mayo Clinic Rochester Minnesota 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