{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:33:11Z","timestamp":1773419591998,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2021\u201000328"],"award-info":[{"award-number":["2021\u201000328"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Children and adolescents treated for a brain tumor suffer from more fatigue than survivors of other types of childhood cancer. As tumor location might be predictive of fatigue, our aim was to investigate the longitudinal development of fatigue in children with brain tumors and risk factors for fatigue separately for different tumor locations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Fatigue was assessed 1235 times for 425 participants. Self\u2010report versions of PedsQL Multidimensional Fatigue Scale were used to repeatedly assess fatigue from the end of treatment up to 8\u00a0years later. Mixed models were used to analyze fatigue over time and determinants separately for infratentorial (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0205), supratentorial hemispheric (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a091), and supratentorial midline tumors (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0129).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cognitive fatigue worsened with time, while sleep\u2010rest and general fatigue first decreased and then increased. There was no difference in fatigue between the tumor locations, but the risk factors differed when stratified by location. Radiotherapy was associated with more fatigue for infratentorial tumors, and centralization of care was associated with less fatigue for the supratentorial midline tumors. For supratentorial hemispheric tumors, female sex was associated with more fatigue. Higher parental education was associated with less fatigue regardless of tumor location.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The development of fatigue seems to be more related to sociodemographic and treatment variables than to tumor location. Healthcare providers need to be aware that fatigue may develop in the years following end of treatment, and that patients with a low\/middle educational family background might be more vulnerable and in need of targeted support.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.31028","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T23:48:52Z","timestamp":1714693732000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The development of fatigue after treatment for pediatric brain tumors does not differ between tumor locations"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9875-1341","authenticated-orcid":false,"given":"Elin","family":"Irestorm","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Paediatrics Lund University  Lund Sweden"},{"name":"Department of Pediatric Endocrinology Princess M\u00e1xima Center for Pediatric Oncology Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoinette Y. N.","family":"Schouten\u2010van Meeteren","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Princess M\u00e1xima Center for Pediatric Oncology Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marloes","family":"van Gorp","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Princess M\u00e1xima Center for Pediatric Oncology Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos W. R.","family":"Twisk","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Data Science, Amsterdam UMC, Location VU University Medical Center Amsterdam Public Health Research Institute  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanneke M.","family":"van Santen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Princess M\u00e1xima Center for Pediatric Oncology Utrecht The Netherlands"},{"name":"Department of Pediatric Endocrinology Wilhelmina Children's Hospital, UMCU Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marita","family":"Partanen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Princess M\u00e1xima Center for Pediatric Oncology Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha A.","family":"Grootenhuis","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Princess M\u00e1xima Center for Pediatric Oncology Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphaele R. L.","family":"van Litsenburg","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology Princess M\u00e1xima Center for Pediatric Oncology Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/jayao.2014.0023"},{"key":"e_1_2_10_3_1","first-page":"1","article-title":"Recommendations for the surveillance of cancer\u2010related fatigue in childhood, adolescent, and young adult cancer survivors: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group","author":"Christen S","year":"2020","journal-title":"J Cancer Surviv"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt242"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010023\u201002339\u2010y"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33993"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40359\u2010020\u201000398\u20101"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20609"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/31.2.271"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2023.2254477"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22157"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2011.37.0577"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2005.10.190"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-009-9580-1"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26976"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26481"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10428"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20609"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25730"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1037\/cpp0000043"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28827"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136\u2010010\u20109836\u20109"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012681.pub2"},{"key":"e_1_2_10_24_1","unstructured":"Volksgezondheid en Zorg.Educational stratification.Volksgezondheid en Zorg. 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