{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T07:10:28Z","timestamp":1773645028587,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T00:00:00Z","timestamp":1716336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Metronomic chemotherapy\u2010based combinations have received interest for relapsed\/refractory malignancies. Preclinical and clinical studies showed activity of metronomic etoposide and axitinib. We report our retrospective experience in six children treated with axitinib and metronomic etoposide for refractory\/relapsed brain tumors as an \u201coff\u2010label\u201d combination. Three patients with medulloblastoma experienced partial response; one patient with atypical teratoid rhabdoid tumor (ATRT) displays an ongoing stable disease (12\u00a0months); two patients with medulloblastoma had progressive disease. Grade 3\u20134 toxicities were observed in two patients (thrombocytopenia, anemia, diarrhea, fatigue). The axitinib\u2013etoposide combination shows signals of efficacy in heavily pretreated patients with relapsed\/refractory brain tumors. These results were based on real\u2010world observation and will need formal evaluation in a phase I\/II trial.<\/jats:p>","DOI":"10.1002\/pbc.31076","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:07:07Z","timestamp":1716422827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Retrospective experience of children with relapsed brain tumors treated with oral combination of axitinib and metronomic etoposide"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3526-1855","authenticated-orcid":false,"given":"Caroline","family":"Donz\u00e9","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology, Immunology and Oncology, APHM La Timone Children's Hospital  Marseille 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