{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:54:15Z","timestamp":1785545655698,"version":"3.56.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000982","name":"Conquer Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000982","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006058","name":"St. Baldrick's Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006058","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chimeric antigen receptor (CAR) T\u2010cell therapy provides promising outcomes in relapsed\/refractory B acute lymphoblastic leukemia (ALL), yet still carries high toxicity rates and relatively poor long\u2010term survival. Efficacy has yet to be demonstrated in other diagnoses while toxicity and risk profiles remain formidable. To date, treatment\u2010related symptom burden is gleaned from clinical trial toxicity reports; the patient perspective remains understudied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>English\u2010 or Spanish\u2010speaking patients (ages 8\u201325\u00a0years) undergoing CAR T\u2010cell therapy for any malignancy and their primary caregivers were recruited from Seattle Children's Hospital (SCH), St. Jude Children's Research Hospital (SJCRH), and the Pediatric Oncology Branch of the National Cancer Institute (NCI). Both patient and caregiver completed semi\u2010structured dyadic interviews 3\u00a0months post treatment. We used directed content analysis for codebook development and thematic network analysis for inductive qualitative analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty families completed interviews (13 patients, 15 parents). Patients were a median age 16.5\u00a0years, predominantly female (65%), White (75%), and diagnosed with ALL (75%). Global themes included \u201cA clear decision,\u201d \u201cCoping with symptoms,\u201d and \u201cUnforeseen psychosocial challenges.\u201d When families were asked to describe the \u201cmost challenging part of treatment,\u201d most described \u201cthe unknown.\u201d Most reported \u201cthe symptoms really weren't that bad,\u201d even among patients hospitalized for severe toxicity events. Fatigue, pain, and nausea were the most prevalent symptoms. Importantly, only one family would have chosen a different therapy, if given another opportunity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although physical symptoms were largely tolerable, recognizing supportive care opportunities remains imperative, particularly psychosocial concerns.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31092","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T04:19:21Z","timestamp":1718252361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Weathering the storm when the end of the road is near: A qualitative analysis of supportive care needs during CAR T\u2010cell therapy in pediatrics"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8000-0179","authenticated-orcid":false,"given":"Angela","family":"Steineck","sequence":"first","affiliation":[{"name":"MACC Fund Center for Cancer and Blood Disorders Department of Pediatrics Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara K.","family":"Silbert","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Branch National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kallie","family":"Palm","sequence":"additional","affiliation":[{"name":"MACC Fund Center for Cancer and Blood Disorders Department of Pediatrics Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordyn","family":"Nepper","sequence":"additional","affiliation":[{"name":"Medical School Medical College of Wisconsin  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagny","family":"Vaughn","sequence":"additional","affiliation":[{"name":"College of Medicine Health Sciences Center University of Tennessee  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Shipman","sequence":"additional","affiliation":[{"name":"Center for Cellular Immunotherapies Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haneen","family":"Shalabi","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Branch National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9573-8870","authenticated-orcid":false,"given":"Lori","family":"Wiener","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Branch National Cancer Institute  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam","family":"Comiskey","sequence":"additional","affiliation":[{"name":"Department of Psychosocial Oncology &amp; 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