{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T07:10:36Z","timestamp":1773645036249,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000850","name":"National Heart and Lung Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Opioids are a common and essential treatment for acute sickle cell disease (SCD) pain. However, opioids carry well\u2010known adverse side effects, including potential development of hyperalgesia and nociplastic pain. We characterized opioid use in youth with SCD using ecological momentary assessment (EMA) data, and investigated the relationships between home\u2010based opioid use, pain, and a range of biopsychosocial factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Eighty\u2010eight youth with SCD (aged 8\u201317\u00a0years) completed EMAs assessing home\u2010based opioid use, pain, and related factors. Analyses consisted of descriptive and multilevel logistic regression to predict daily home opioid use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Youth averaged 3.64\u00a0weeks of EMAs. Approximately 35% of the sample (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a031) took an opioid during the EMA period, and used them on only 24% of reported pain days. Youth who took opioids reported a higher percentage of pain days (\n                      <jats:italic>t<\/jats:italic>\n                      \u00a0=\u00a0\u22122.67,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05) and mean pain severity scores (\n                      <jats:italic>t<\/jats:italic>\n                      \u00a0=\u00a0\u22122.30,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.05) than youth who did not take opioids. Multilevel logistic regression analyses indicated that high daily pain severity (odds ratio [OR]\u00a0=\u00a01.02,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01), older age (OR\u00a0=\u00a01.324,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01), and low positive affect (OR\u00a0=\u00a00.91,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a0.01) were each related to an increased likelihood of opioid use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Youth with SCD take opioids appropriately in response to their pain, based on daily self\u2010report. Beyond daily pain severity, age, and daily variation in positive affect were related to home\u2010based opioid use. This suggests that behavioral interventions that enhance positive affect may promote reduced opioid use among youth with SCD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.31116","type":"journal-article","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T23:29:02Z","timestamp":1716852542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Investigating home\u2010based opioid use among youth with sickle cell disease using ecological momentary assessment"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7204-6812","authenticated-orcid":false,"given":"Cecelia","family":"Valrie","sequence":"first","affiliation":[{"name":"Department of Psychology Virginia Commonwealth University  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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