{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T18:03:30Z","timestamp":1770228210820,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1UL1TR001430"],"award-info":[{"award-number":["1UL1TR001430"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Rationale<\/jats:title><jats:p>Acute chest syndrome (ACS) often develops during hospitalizations for sickle cell disease (SCD) vaso\u2010occlusive episodes and may be triggered by a combination of chest wall splinting, opioid use, hypoventilation, and atelectasis. In 2017, Boston Medical Center's general pediatric inpatient unit instituted the novel use of bi\u2010level positive airway pressure (BiPAP) as \u201csupportive non\u2010invasive ventilation for ACS prevention\u201d (SNAP) to prevent ACS and respiratory decompensation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The goals of this qualitative study were to identify perceived benefits, harms, facilitators, and barriers to use of SNAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted semi\u2010structured key informant interviews at three sites with different levels of SNAP implementation (Site 1: extensive implementation; Site 2: limited implementation; Site 3: not yet implemented) regarding experiences with and\/or perceptions of SNAP. Interviews and coding were guided by the Promoting Action on Research Implementation in Health Services (PARiHS) framework.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010four participants (physicians, nurses, respiratory therapists, child life specialists, psychologists, youth with SCD, and parents) completed interviews. Major themes included: (i) participants perceive BiPAP as effective at preventing ACS, and for those with medically stable ACS, for preventing respiratory decompensation. (ii) BiPAP use is appropriate on the general pediatric inpatient unit for medically stable patients with SCD. (iii) Improving the patient experience is the most important factor to optimize acceptance of BiPAP by patients and families.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion\/future directions<\/jats:title><jats:p>SNAP is perceived as effective and appropriate for hospitalized pediatric patients with SCD. Improving the patient experience is the biggest challenge. These data will inform a future protocol for a multicenter hybrid effectiveness\/implementation trial of SNAP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31142","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T12:34:14Z","timestamp":1718800454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["SNAP: Supportive non\u2010invasive ventilation for acute chest syndrome prevention for hospitalized children with sickle cell disease: Perspectives of patients, parents, and the healthcare team"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6902-3118","authenticated-orcid":false,"given":"Robyn T.","family":"Cohen","sequence":"first","affiliation":[{"name":"Department of Pediatrics Boston Medical Center  Boston Massachusetts USA"},{"name":"Sickle Cell Disease Center of Excellence Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shana A. B.","family":"Burrowes","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Medicine Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Evans Center for Implementation and Improvement Sciences Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Williams","sequence":"additional","affiliation":[{"name":"Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin M.","family":"Neri","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Boston Medical Center  Boston Massachusetts USA"},{"name":"Sickle Cell Disease Center of Excellence Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth S.","family":"Klings","sequence":"additional","affiliation":[{"name":"Sickle Cell Disease Center of Excellence Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"},{"name":"Pulmonary Center, Department of Medicine Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayla C.","family":"Jones","sequence":"additional","affiliation":[{"name":"Evans Center for Implementation and Improvement Sciences Boston University Chobanian and Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan J.","family":"Walkey","sequence":"additional","affiliation":[{"name":"Division of Health Systems Science UMass Chan Medical School  Worcester Massachusetts 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