{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:50:41Z","timestamp":1791561041540,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite the excellent outcomes achieved in the treatment of pediatric Burkitt lymphoma (BL) in high\u2010income countries (HICs), outcomes remain poor in low\u2010 and middle\u2010income countries (LMICs). Efforts to improve BL outcomes in Tanzania included the creation of National Treatment Guidelines in 2016. However, disease outcomes in Tanzania following the creation of these guidelines have not been reported to date.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Historical records from 2016 to 2021 for patients 0\u201318\u00a0years of age with a diagnosis of BL and seen at Bugando Medical Centre (BMC), in Mwanza, Tanzania, were curated into an electronic database and analyzed descriptively. Patients in this cohort were treated per the Tanzanian National Treatment Guidelines, which include six cycles of cyclophosphamide, vincristine, and methotrexate (COM) chemotherapy with intrathecal methotrexate and cytarabine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 92 BL patients\u2019 records were eligible for analysis. Patients in this cohort were most commonly Murphy stage II (28%) or stage III (34%). Nearly all, 91%, met International Network for Cancer Treatment and Research (INCTR) high\u2010risk criteria at presentation. Forty\u2010two percent of patients did not receive a biopsy and were treated with a presumed diagnosis of BL alone. A 1\u2010year event\u2010free survival of 29.6% (95% confidence interval [CI]: 20.3%\u201339.5%) and a 1\u2010year overall survival of 38.5% (95% CI: 28%\u201348.9%) were observed. A high rate of treatment abandonment (34%) was also observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In a historical cohort of pediatric patients with BL treated per the 2016 Tanzanian National Treatment Guidelines, we observed poor outcomes and a high rate of abandonment. These outcomes appear inferior to those achieved in the INCTR clinical trial that informed the guidelines\u2019 creation, and highlights the importance of \u201creal\u2010world\u201d outcomes data in LMICs. These data reinforce the idea that continued clinical research and capacity building efforts are necessary to improve BL outcomes in LMICs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31145","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T05:45:37Z","timestamp":1719294337000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Retrospective analysis of pediatric patients with Burkitt lymphoma treated in Tanzania following the implementation of the 2016 National Treatment Guidelines: Poor outcomes to current standard\u2010of\u2010care therapy"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5574-8532","authenticated-orcid":false,"given":"Hutton","family":"Chapman","sequence":"first","affiliation":[{"name":"Duke University Hospital  Durham North Carolina USA"},{"name":"Duke Global Health Institute  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo S.","family":"Ntemi","sequence":"additional","affiliation":[{"name":"Bugando Medical Centre  Mwanza Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mwitasrobert","family":"Gisiri","sequence":"additional","affiliation":[{"name":"Muhimbili University of Health and Allied Sciences  Dar es Salaam Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lavanya","family":"Vasudevan","sequence":"additional","affiliation":[{"name":"Duke Global Health Institute  Durham North Carolina USA"},{"name":"Hubert Department of Global Health Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heronima J.","family":"Kashaigili","sequence":"additional","affiliation":[{"name":"Bugando Medical Centre  Mwanza Tanzania"},{"name":"Catholic University of Allied and Health Sciences  Mwanza Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6433-6174","authenticated-orcid":false,"given":"Kristin","family":"Schroeder","sequence":"additional","affiliation":[{"name":"Duke University Hospital  Durham North Carolina USA"},{"name":"Duke Global Health Institute  Durham North Carolina USA"},{"name":"Bugando Medical Centre  Mwanza Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization.CureAll framework: WHO global initiative for childhood cancer: increasing access advancing quality saving lives.World Health Organization;2021. 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