{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T18:31:08Z","timestamp":1775932268017,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The capacity of presurgical image\u2010defined risk factors (IDRFs) to predict secondary surgical outcomes in patients with neuroblastoma is controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The International Neuroblastoma Surgical Report Form (INSRF) was employed to retrospectively collect the clinical data of 53 patients diagnosed with neuroblastoma at our hospital from April 2014 to April 2020. IDRFs were identified at the time of diagnosis and reassessed during the course of neoadjuvant chemotherapy. Various statistical tests were used to evaluate the correlation between IDRFs and secondary surgical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 195 IDRFs were identified. Notably, by two courses of neoadjuvant chemotherapy, the number of \u201ctwo body compartments,\u201d \u201cintraspinal tumor extension,\u201d and \u201ctrachea\u2010compressing\u201d IDRFs decreased significantly (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.001). The primary tumor volumes and the number of IDRFs decreased significantly by four courses of neoadjuvant chemotherapy, especially in \u201cintraspinal tumor extension\u201d IDRFs (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.034). The median number of IDRF per patient was four (interquartile range [IQR]: 1\u20135) at diagnosis, which diminished to one (IQR: 1\u20133) subsequent to neoadjuvant chemotherapy. The presence of preoperative IDRFs was not associated with surgical complications (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.286) or the extent of surgery (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.188). However, the number of preoperative IDRFs linked to the extent of surgery (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.002), not to operative complications (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.669). Specifically, presurgery \u201crenal vessel contact\u201d IDRFs were predictive of surgical complications, while presurgery \u201cinfiltration of vital structures\u201d IDRFs were associated with the extent of surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The number of IDRFs decreased significantly by four courses of neoadjuvant chemotherapy. The number and type of presurgery IDRFs may predict secondary surgical outcomes, surpassing the mere consideration of their presence or absence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31161","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T05:11:22Z","timestamp":1720674682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tracking changes in image\u2010defined risk factors during neoadjuvant chemotherapy and their predictive value for surgical outcomes based on the International Neuroblastoma Surgical Report Form"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1291-3128","authenticated-orcid":false,"given":"Tao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of General Surgery, Shanghai Children's Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai 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Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Shanghai Children's Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, Shanghai Children's Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiujun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shanghai Children's Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangbin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of 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