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Information on long\u2010term outcomes following an acute neurotoxic event is limited. Therefore, this report compares neurocognitive performance more than 12\u00a0months post diagnosis (mean\u00a0=\u00a04\u00a0years) between ALL patients with (<jats:italic>n<\/jats:italic>\u00a0=\u00a025) and without (<jats:italic>n<\/jats:italic>\u00a0=\u00a0146) a history of acute neurotoxicity. Compared to children with no documented on\u2010treatment neurotoxic event, children who experienced a neurotoxic event during treatment exhibited poorer performance on measures of fine motor function (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.02) and attention (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.02). Children with ALL who experience acute neurotoxicity may be candidates for early neuropsychological screening and intervention.<\/jats:p>","DOI":"10.1002\/pbc.31169","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T04:53:48Z","timestamp":1720068828000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Episodes of acute methotrexate\u2010related neurotoxicity linked to compromised long\u2010term neurocognitive function"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8191-5477","authenticated-orcid":false,"given":"Rachel D.","family":"Harris","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Hematology\/Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga A.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Hematology\/Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9332-181X","authenticated-orcid":false,"given":"Kimberly P.","family":"Raghubar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Psychology Baylor College of Medicine  Houston Texas USA"},{"name":"Department of Pediatric Psychology and Neuropsychology Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0947-104X","authenticated-orcid":false,"given":"Mariana","family":"Matheus Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Hematology\/Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0997-906X","authenticated-orcid":false,"given":"Mark","family":"Zobeck","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Hematology\/Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Monica","family":"Gramatges","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Hematology\/Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen R.","family":"Rabin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Hematology\/Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Scheurer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Hematology\/Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5802-5073","authenticated-orcid":false,"given":"Austin L.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Hematology\/Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.62.4544"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.11.4243"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(16)30110\u20107"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26436"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.16077"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21869"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21544"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21700"},{"issue":"1","key":"e_1_2_8_10_1","first-page":"25","article-title":"Neurocognitive late effects of chemotherapy in survivors of acute lymphoblastic leukemia: focus on methotrexate","volume":"24","author":"Plas E","year":"2015","journal-title":"J Can Acad Child Adolesc Psychiatry"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(16)30035\u20103"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20860"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24947"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.0808"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2023.2245093"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.0089"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/1120009X.2020.1805239"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000511937"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001557"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000000"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.117505"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035589"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.31169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T03:35:05Z","timestamp":1721878505000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.31169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,3]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/pbc.31169"],"URL":"https:\/\/doi.org\/10.1002\/pbc.31169","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,3]]},"assertion":[{"value":"2024-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e31169"}}