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Clinical findings of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury arise due to aberrant complement protein activation in the circulation. A 13\u2010month\u2010old boy with metastatic neuroblastoma (NB) developed aHUS during his first cycle of induction chemotherapy with germline testing revealing a complement factor H\u00a0(<jats:italic>CFH<\/jats:italic>) gene mutation, currently classified as a variant of uncertain significance (VUS). Now he is in disease remission after successful complement blockade therapy, thus highlighting a unique presentation of aHUS in a patient with newly diagnosed NB.<\/jats:p>","DOI":"10.1002\/pbc.31175","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T04:54:28Z","timestamp":1720068868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Atypical hemolytic uremic syndrome during induction chemotherapy in neuroblastoma, a rare phenomenon or common congenital predisposition?"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2154-933X","authenticated-orcid":false,"given":"Meghan","family":"Davitt","sequence":"first","affiliation":[{"name":"Lisa Dean Mosely Foundation Institute for Cancer and Blood Disorders Nemours Children's Hospital  Wilmington Delaware USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5211-6457","authenticated-orcid":false,"given":"Rachel","family":"Offenbacher","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology, Oncology, and Cellular Therapy, Children's Hospital at Montefiore Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle A.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology, Oncology, and Cellular Therapy, Children's Hospital at Montefiore Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Loeb","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology, Oncology, and Cellular Therapy, Children's Hospital at Montefiore Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1057-1811","authenticated-orcid":false,"given":"Deepa","family":"Manwani","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology, Oncology, and Cellular Therapy, Children's Hospital at Montefiore Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7018-0885","authenticated-orcid":false,"given":"William","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology, Oncology, and Cellular Therapy, Children's Hospital at Montefiore Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Weiser","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology, Oncology, and Cellular Therapy, Children's Hospital at Montefiore Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1470\u20102045(03)01166\u20105"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201011\u2010709865"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001315"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.16.6785"},{"key":"e_1_2_6_6_1","unstructured":"Group CsO. 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