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These tumors are estrogen\u2010producing and can cause symptoms of precocious puberty, gynecomastia, and growth acceleration. Here we discuss our experience with spontaneous resolution or stabilization of breast enlargement without medical intervention in three patients with PJS and gynecomastia. These cases indicate that a watchful waiting approach can be considered in the management of gynecomastia in male children with PJS.<\/jats:p>","DOI":"10.1002\/pbc.31180","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T05:05:01Z","timestamp":1722229501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Conservative management of gynecomastia in Peutz\u2010Jeghers syndrome: Case series and review of the literature"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7434-3282","authenticated-orcid":false,"given":"Myrto","family":"Skafida","sequence":"first","affiliation":[{"name":"Department of Pediatrics State University of New York Downstate Health Sciences University  New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melani M","family":"Duvall","sequence":"additional","affiliation":[{"name":"Department of 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