{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:06:59Z","timestamp":1773493619653,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007311","name":"Deutsche Kinderkrebsstiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007311","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Spinal cord compression is a rare presentation of non\u2010Hodgkin lymphoma (NHL) in children. We aimed to describe the prevalence, histological subtypes, clinical presentation, therapy, and outcome of those children in a population\u2010based cohort. The chemotherapy regimen remained comparable over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively identified all children and adolescents with paresis as initial manifestations of the NHL between January 1990 and December 2020 from the NHL\u2010BFM database. Characteristics, therapy, and outcome data were gathered from the database and patient files.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010seven of 4779 children (1.2%) presented with initial paresis due to spinal cord compression. The median age was 10.3 years (range, 3.1\u201018.0 years), and 33% were female. Initial symptoms were paresis\/weakness (<jats:italic>n<\/jats:italic>\u00a0=\u00a050, 88%), back pain (<jats:italic>n<\/jats:italic>\u00a0=\u00a033, 58%), paresthesia (<jats:italic>n<\/jats:italic>\u00a0=\u00a023, 40%), and bladder dysfunction and\/or constipation (<jats:italic>n<\/jats:italic>\u00a0=\u00a022, 39%), persisting for a median of 14 days before diagnosis. Subtype distribution was mature B\u2010NHL (<jats:italic>n<\/jats:italic>\u00a0=\u00a041, 72%), precursor B\u2010lymphoblastic lymphoma (LBL) (<jats:italic>n<\/jats:italic>\u00a0=\u00a012, 21%), anaplastic large cell lymphoma (ALCL) (<jats:italic>n<\/jats:italic>\u00a0=\u00a03, 5%), and T\u2010LBL (<jats:italic>n<\/jats:italic>\u00a0=\u00a01, 2%). Initial emergency therapy included surgery (70%) and\/or chemotherapy\/steroids (63%). Five\u2010year event\u2010free survival and overall survival (80%\u00a0\u00b1\u00a05% and 82%\u00a0\u00b1\u00a05%, respectively) were comparable with all other NHL patients. Neurological symptoms persisted in approximately one\u2010third of surviving patients at the last follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>1.2% of pediatric NHL patients presented with paresis from spinal cord compression mainly due to B\u2010cell lymphomas. Neurological sequelae were observed in one\u2010third of surviving patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31182","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T04:54:01Z","timestamp":1720068841000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Non\u2010Hodgkin lymphoma presenting with spinal cord compression: A population\u2010based analysis of the NHL\u2010BFM study group"],"prefix":"10.1002","volume":"71","author":[{"given":"Amambay","family":"Riquelme","sequence":"first","affiliation":[{"name":"Pediatric Hematology and Oncology and NHL\u2010BFM Study Centre University Medical Centre Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6399-6960","authenticated-orcid":false,"given":"Jana","family":"Werner","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology and NHL\u2010BFM Study Centre University Medical Centre Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Children's Hospital, Hannover Medical School  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"von Mersi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edita","family":"Kab\u00ed\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology Charles University and University Hospital Motol  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Ceppi","sequence":"additional","affiliation":[{"name":"Pediatric Hematology\u2010Oncology Unit, Division of Pediatrics, Department Woman\u2010Mother\u2010Child University Hospital of Lausanne and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Foerster","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology and NHL\u2010BFM Study Centre University Medical Centre Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmin","family":"Finger","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology and NHL\u2010BFM Study Centre University Hospital Muenster  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology and NHL\u2010BFM Study Centre University Hospital Muenster  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9285-6898","authenticated-orcid":false,"given":"Andishe","family":"Attarbaschi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, St. Anna Children's Hospital Medical University of Vienna  Vienna Austria"},{"name":"St. Anna Children's Cancer Research Institute  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Burkhardt","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology and NHL\u2010BFM Study Centre University Hospital Muenster  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilhelm","family":"Woessmann","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Oncology and NHL\u2010BFM Study Centre University Medical Centre Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001858"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80357-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199902)32:2<102::AID-MPO6>3.0.CO;2-Y"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.03.059"},{"key":"e_1_2_10_6_1","volume-title":"World Health Organization classification of tumours. Pathology and genetics. Tumours of hematopoietic and lymphoid Tissues","author":"Jaffe ESHN","year":"2001"},{"key":"e_1_2_10_7_1","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_10_8_1","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow SH,","year":"2017"},{"issue":"3","key":"e_1_2_10_9_1","first-page":"332","article-title":"Classification, staging and end results of treatment of childhood non\u2010Hodgkin's lymphomas: dissimilarities from lymphomas in adults","volume":"7","author":"Murphy SB","year":"1980","journal-title":"Semin Oncol"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.59.7203"},{"issue":"10","key":"e_1_2_10_11_1","first-page":"3294","article-title":"Improved treatment results in childhood B\u2010cell neoplasms with tailored intensification of therapy: a report of the Berlin\u2010Frankfurt\u2010Munster Group Trial NHL\u2010BFM 90","volume":"94","author":"Reiter A","year":"1999","journal-title":"Blood"},{"issue":"2","key":"e_1_2_10_12_1","first-page":"416","article-title":"Intensive ALL\u2010type therapy without local radiotherapy provides a 90% event\u2010free survival for children with T\u2010cell lymphoblastic lymphoma: a BFM group report","volume":"95","author":"Reiter A","year":"2000","journal-title":"Blood"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.12.3699"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-0973"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.2707"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.139162"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.1487"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12102747"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.6791"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_10_21_1","volume-title":"The statistical analysis of failure time data","author":"Kalbfleisch JD","year":"1980"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1214\/aos\/1176350951"},{"key":"e_1_2_10_23_1","volume-title":"P\u00e4diatrische H\u00e4matologie und Onkologie","author":"Burkhardt B, Klapper W","year":"2018"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.11.3370"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12042"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08541.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-023-07820-3"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26451"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.1.183"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199905)32:5<353::AID-MPO8>3.0.CO;2-2"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23037"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.3171\/PED-08\/01\/057"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80996-8"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(99)00265-8"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.31182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T03:33:15Z","timestamp":1721878395000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.31182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,3]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/pbc.31182"],"URL":"https:\/\/doi.org\/10.1002\/pbc.31182","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,3]]},"assertion":[{"value":"2024-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e31182"}}