{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T22:24:07Z","timestamp":1782080647518,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High\u2010dose methotrexate (HD\u2010MTX) is used in the treatment of children with central nervous system (CNS) tumors; however, toxicity information is limited. We characterized toxicities following 102 administrations of HD\u2010MTX (4.6\u201313.5\u00a0g\/m<jats:sup>2<\/jats:sup>) infused over 4 or 24\u00a0h in 38 children with a CNS tumor before 6 years of age (2010\u20132020). Delayed clearance of methotrexate occurred following 24% of infusions. Common Terminology Criteria for Adverse Events v5 grade 2\u20133 mucositis was observed in 47% of individuals, Grade 4 neutropenia in 76%, and grade 3\u20134 thrombocytopenia in 58%. No neurotoxicity was observed. HD\u2010MTX can be safely used with supportive care and monitoring.<\/jats:p>","DOI":"10.1002\/pbc.31213","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T05:18:41Z","timestamp":1721711921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Toxicity profile of high\u2010dose methotrexate in young children with central nervous system tumors"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7986-601X","authenticated-orcid":false,"given":"Ashley N.","family":"Chavana","sequence":"first","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary L.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Division of Translational and Clinical Pharmacology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Cancer and Blood Diseases Institute Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"DeGroote","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Aflac Cancer &amp; Blood Disorders Center, Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5654-841X","authenticated-orcid":false,"given":"Holly B.","family":"Lindsay","sequence":"additional","affiliation":[{"name":"Center for Cancer and Blood Disorders Children's Hospital Colorado  Aurora Colorado USA"},{"name":"Department of Pediatrics University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2333-4364","authenticated-orcid":false,"given":"Hannah E.","family":"Sauer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.","family":"Mason","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7063-512X","authenticated-orcid":false,"given":"Eric S.","family":"Schafer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4250-5376","authenticated-orcid":false,"given":"Tamara P.","family":"Miller","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Aflac Cancer &amp; Blood Disorders Center, Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon M.","family":"Castellino","sequence":"additional","affiliation":[{"name":"Division of Pediatrics Emory University School of Medicine  Atlanta Georgia USA"},{"name":"Aflac Cancer &amp; Blood Disorders Center, Children's Healthcare of Atlanta  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8760-5202","authenticated-orcid":false,"given":"Lauren","family":"Pommert","sequence":"additional","affiliation":[{"name":"Cancer and Blood Diseases Institute Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen M.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Cancer and Blood Diseases Institute Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6417-3961","authenticated-orcid":false,"given":"Laura B.","family":"Ramsey","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Toxicology &amp; Therapeutic Innovation Children's Mercy Kansas City  Kansas City Missouri USA"},{"name":"Department of Pediatrics School of Medicine University of Missouri Kansas City  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9612-3624","authenticated-orcid":false,"given":"M. Brooke","family":"Bernhardt","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Pharmaceutical Science St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5802-5073","authenticated-orcid":false,"given":"Austin L.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center Texas Children's Hospital  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2015\u20100164"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2023.106669"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288\u2010019\u201001245\u2010z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5863\/1551\u20106776\u201019.4.262"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280\u2010016\u20103008\u20108"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14160"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280\u2010014\u20102614\u20106"},{"key":"e_1_2_8_9_1","unstructured":"Services USDoHaH.Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.2017."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01776"},{"key":"e_1_2_8_11_1","first-page":"S12","article-title":"ACNS0334: treatment of young children, with supratentorial PNET (SPNET) and high risk medulloblastoma (HRMB) without or with high dose methotrexate (HDMTX). 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