{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T06:37:24Z","timestamp":1793515044343,"version":"4.5.0"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Comprehensive guidelines for the management of iron deficiency anemia (IDA) in adolescents with heavy menstrual bleeding (HMB) presenting to the emergency department (ED) are lacking, leading to variability in care. We aimed to standardize the evaluation and management of these patients through the development and implementation of an evidence\u2010based algorithm using quality improvement methodology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Baseline data of the target population identified variability across four key measures of clinical management: therapy choice and administration, laboratory evaluation, hematology service consultation, and patient disposition. Literature review and consensus from pediatric hematology and gynecology providers informed a draft algorithm that was refined in an iterative multidisciplinary process. From December 2022 to July 2023, we aimed to achieve a 25% relative increase in patients to receive optimal management per the algorithm, while using sequential Plan\u2013Do\u2013Study\u2013Act (PDSA) cycles. Process measures focusing on provider documentation and balancing measures, such as ED length of stay, were assessed concurrently.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010nine patients were evaluated during four PDSA cycles. Improvement of \u226540% above baseline regarding recommended therapy administration was achieved across four PDSA cycles. Adherence to recommended therapy choice improved from 57% (baseline) to 100%, minimal laboratory evaluation from 14% to 83%, hematology consultation from 36% to 100%, and appropriate disposition from 71% to 100%. ED length of stay remained stable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Implementation of a standardized algorithm for management of IDA secondary to HMB in adolescents in the ED increased adherence to evidence\u2010based patient care.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31222","type":"journal-article","created":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T05:34:39Z","timestamp":1721972079000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Standardizing the evaluation and management of iron deficiency anemia secondary to heavy menstrual bleeding in the emergency department"],"prefix":"10.1002","volume":"71","author":[{"given":"Josaura","family":"Fernandez Sanchez","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Hematology\u2010Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6506-4772","authenticated-orcid":false,"given":"Luisanna M.","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology\u2010Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah S.","family":"Kappa","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology\u2010Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8901-0261","authenticated-orcid":false,"given":"Cecile L.","family":"Karsenty","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology\u2010Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"O'Keefe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology\u2010Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan","family":"Shekar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology\u2010Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leander D.","family":"Timothy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology\u2010Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea B.","family":"Vrana","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology\u2010Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladstone","family":"Airewele","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology\u2010Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YoungNa","family":"Lee\u2010Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology\u2010Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Fatih","family":"Okcu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology\u2010Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6819-4049","authenticated-orcid":false,"given":"Clay T.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology\u2010Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacquelyn M.","family":"Powers","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology\u2010Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003411"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2012.07.001"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2017.01.002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1083\u20103188(98)70101\u20109"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2012.05.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016346609158455"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954\u20106820.1966.tb02880.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.11.016"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12046"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2014.09.027"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2021.12.016"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14626"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30181"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475\u20106773.2006.00567.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2016.10.010"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000002591"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2023.01.017"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2018.06.008"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325\u2010020\u201001564\u2010y"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13330"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.31222","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T05:39:03Z","timestamp":1737178743000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.31222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,25]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/pbc.31222"],"URL":"https:\/\/doi.org\/10.1002\/pbc.31222","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,25]]},"assertion":[{"value":"2024-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e31222"}}