{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:11:53Z","timestamp":1790781113338,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment for certain childhood cancers and nonmalignant conditions can lead to future infertility and gonadal failure. The risk of treatment delay must be considered when offering fertility preservation (FP) options. We examined the timeline from FP referral to return to treatment (RTT) in pediatric patients who underwent FP due to iatrogenic risk for infertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review was performed of patients with FP consultation due to an increased risk of iatrogenic infertility at Ann &amp; Robert H. Lurie Children's Hospital of Chicago from 2018 to 2022. Data on diagnosis, age, treatment characteristics, and procedure were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 337 patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0149 with ovaries, <jats:italic>n<\/jats:italic>\u00a0=\u00a0188 with testes) had an FP consultation. Of patients with ovaries, 106 (71.1%) underwent ovarian tissue cryopreservation (OTC), 10 (6.7%) completed ovarian stimulation\/egg retrieval (OSER), and 33 (22.1%) declined FP. Of the patients with testes, 98 (52.1%) underwent testicular tissue cryopreservation (TTC), 48 (25.5%) completed sperm banking (SB), and 42 (22.3%) declined FP. Median time from referral to FP consultation was short (ovaries: 2\u00a0days, range: 0\u20136; testes: 1\u00a0day, range: 0\u20135). OSER had a significantly longer RTT versus OTC and no FP (52.5 vs.19.5 vs. 12\u00a0days, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01). SB had a significantly quicker RTT compared to TTC or no FP (9.0 vs. 21.0 vs. 13.5\u00a0days; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.008). For patients who underwent OTC\/TTC and those who declined FP, there was no significant difference in time from consultation to treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It is feasible to promptly offer and complete FP with minimal delay to disease\u2010directed treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31232","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T03:56:04Z","timestamp":1722484564000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comprehensive fertility preservation can be offered in a timely manner around gonadotoxic therapy in children and adolescents"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3708-8280","authenticated-orcid":false,"given":"Kathryn L.","family":"McElhinney","sequence":"first","affiliation":[{"name":"Fertility &amp; Hormone Preservation &amp; Restoration Program Division of Pediatric Surgery Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"},{"name":"Division of Pediatric Surgery Department of Surgery Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Stanley Manne Children's Research Institute Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha K.","family":"McLean","sequence":"additional","affiliation":[{"name":"Fertility &amp; Hormone Preservation &amp; Restoration Program Division of Pediatric Surgery Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"},{"name":"Division of Pediatric Surgery Department of Surgery Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Zarnegar\u2010Lumley","sequence":"additional","affiliation":[{"name":"Division of Hematology Oncology, Neuro\u2010Oncology &amp; Stem Cell Transplantation Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"},{"name":"Department of Pediatrics Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica M.","family":"Laronda","sequence":"additional","affiliation":[{"name":"Fertility &amp; Hormone Preservation &amp; Restoration Program Division of Pediatric Surgery Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"},{"name":"Division of Pediatric Surgery Department of Surgery Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Stanley Manne Children's Research Institute Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"},{"name":"Division of Endocrinology Department of Pediatrics Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Department of Obstetrics and Gynecology Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin E.","family":"Rowell","sequence":"additional","affiliation":[{"name":"Fertility &amp; Hormone Preservation &amp; Restoration Program Division of Pediatric Surgery Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"},{"name":"Division of Pediatric Surgery Department of Surgery Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Stanley Manne Children's Research Institute Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.78.1914"},{"key":"e_1_2_9_3_1","unstructured":"National Comprehensive Cancer Network.NCCN Guidelines Version 1.2019 Adolescent and Young Adult Oncology.National Comprehensive Cancer Network;2018. 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