{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:39:42Z","timestamp":1769755182211,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A rare lymphoproliferative disorder involving thrombocytopenia (T), anasarca (A), fever (F), reticulin fibrosis (R), renal dysfunction (R), and organomegaly (O), called TAFRO syndrome, was first reported in 2010. Considered a variant of idiopathic multicentric Castleman's disease, the recent discovery and rarity of this syndrome pose challenges to diagnosis and management. Herein, we review three pediatric cases, including an infant, that illustrate the heterogeneity of TAFRO syndrome. Despite differences in presentation and treatment responses, all patients experienced excellent outcomes. This multi\u2010institutional case series highlights the need to work toward earlier diagnosis and improved long\u2010term management recommendations for patients with TAFRO syndrome.<\/jats:p>","DOI":"10.1002\/pbc.31234","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T05:14:03Z","timestamp":1722489243000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pediatric TAFRO syndrome: A multi\u2010institution case series illustrating clinical challenges and excellent outcomes"],"prefix":"10.1002","volume":"71","author":[{"given":"Amanda K.","family":"Johnson","sequence":"first","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology University of Utah\/Intermountain Health Primary Children's Hospital  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6510-0577","authenticated-orcid":false,"given":"Sasidhar","family":"Goteti","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology University of Utah\/Intermountain Health Primary Children's Hospital  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bar","family":"Devald","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology University of Utah\/Intermountain Health Primary Children's Hospital  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelby","family":"Mestnik","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology University of Minnesota\/M Health Fairview Masonic Children's Hospital Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taumoha","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology University of Utah\/Intermountain Health Primary Children's Hospital  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology University of Minnesota\/M Health Fairview Masonic Children's Hospital Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth S.","family":"Doughty","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Utah  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A.","family":"Linden","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Minnesota\/M Health Fairview Masonic Children\u2018s Hospital  Minnesota Minneapolis USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7127-6889","authenticated-orcid":false,"given":"Amy","family":"Beckman","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Minnesota\/M Health Fairview Masonic Children\u2018s Hospital  Minnesota Minneapolis USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Todd","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Pathology Oregon Health &amp; Science University\/Doernbecher Children\u2018s Hospital  Oregon Portland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey","family":"Richardson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Nephrology Oregon Health &amp; Science University\/Doernbecher Children\u2019s Hospital  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Oregon Health &amp; Science University\/Doernbecher Children\u2019s Hospital  Portland Oregon USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2017.09.009"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1634\/Ftheoncologist.2010\u20100212"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201010\u2010746933"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010022\u201004762\u20106"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S127822"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010019\u201002780\u20101"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201007\u2010862334"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehpc.2017.04.003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388\u2010020\u20101204\u20109"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25554"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.31234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T05:40:02Z","timestamp":1737178802000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.31234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,31]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1002\/pbc.31234"],"URL":"https:\/\/doi.org\/10.1002\/pbc.31234","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,31]]},"assertion":[{"value":"2024-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e31234"}}