{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:47:16Z","timestamp":1790815636878,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T00:00:00Z","timestamp":1722729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21ck0106677"],"award-info":[{"award-number":["JP21ck0106677"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21ck0106676"],"award-info":[{"award-number":["JP21ck0106676"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypomethylating agent treatment for myeloid leukemia associated with Down syndrome (ML\u2010DS) has been scarcely reported. Herein, we collected information on azacitidine treatment for ML\u2010DS in Japan. Forty\u2010eight cycles of azacitidine treatment were performed for 12 patients, including 11 relapsed or refractory (R\/R) patients. In 40 cycles, azacitidine was used as monotherapy. No azacitidine\u2010related death was observed. One cycle concurrently administered with methotrexate\u2010based intrathecal therapy was discontinued due to toxicities. Only 4 of the 19 cycles given in non\u2010remission achieved complete or partial remission. In conclusion, although most toxicities were acceptable, azacitidine monotherapy might be insufficient for R\/R ML\u2010DS cases.<\/jats:p>","DOI":"10.1002\/pbc.31244","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T04:58:04Z","timestamp":1722833884000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Azacitidine treatment for myeloid leukemia associated with Down syndrome: A nationwide retrospective study in Japan"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3656-2665","authenticated-orcid":false,"given":"Shota","family":"Kato","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine The University of Tokyo  Tokyo 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