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In the previous JPLT2 study, cases with resectable tumors without any annotation factors in the PRETEXT (PRETreatment EXTent of disease) classification (standard\u2010risk HB) showed favorable outcomes with treatment consisting of CDDP and pirarubicin, but showed toxicities and late complications. In the JPLT3\u2010S trial, a less intense regimen consisting of CDDP alone was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who were less than 3\u00a0years of age and with PRETEXT I, II, or III HB without any annotation factors (e.g., E1, E1a, E2, E2a, H1, N1, P2, P2a, V3, and V3a) were eligible for inclusion in this study. In this trial, the central radiological and pathological features of all patients were reviewed. The primary outcome was the 3\u2010year progression\u2010free survival (PFS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 38 patients (23 female) were included. The median patient age was 12\u00a0months (range: 2\u201334). Two patients discontinued treatment because of progressive disease, and five patients discontinued treatment for other reasons. The 3\u2010year PFS rate was 93.9% (95% confidence interval [CI]: 86.4%\u2013100%). All 38 patients survived (follow\u2010up period 38\u201398\u00a0months), and the OS rate was 100% (CI: 100). Eighteen of the 38 patients (47.4%) experienced ototoxicity as a late complication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CDDP monotherapy regimen is feasible in young patients with localized HB, as classified by a central review.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31255","type":"journal-article","created":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T12:09:58Z","timestamp":1723291798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Successful treatment of young childhood standard\u2010risk hepatoblastoma with cisplatin monotherapy using a central review system"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2861-0225","authenticated-orcid":false,"given":"Isamu","family":"Saeki","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery Hiroshima University Hospital  Hiroshima 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