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We describe our institutional experience and approach to the management of 11 infants with occlusive or nearly occlusive aortic thrombosis. We observed at least partial thrombus resolution in all patients. Complications related to our management included minor bleeding in two children receiving thrombolytic therapy, and two major bleeding events in children receiving anticoagulation alone. Our experience adds to the growing body of evidence that thrombolysis and thrombectomy should be considered in managing neonatal\/infant aortic thrombosis.<\/jats:p>","DOI":"10.1002\/pbc.31283","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T05:29:40Z","timestamp":1723872580000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Management of neonatal and infant aortic thrombosis: A single\u2010center case series"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3138-5671","authenticated-orcid":false,"given":"Ajibike","family":"Lapite","sequence":"first","affiliation":[{"name":"Division of Hematology\/Oncology Department of Pediatrics Baylor College of Medicine Texas Children's Cancer and Hematology Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4606-2269","authenticated-orcid":false,"given":"Mohammad H.","family":"Abu\u2010Arja","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Pediatrics Baylor College of Medicine Texas Children's Cancer and Hematology Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyojeong","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Children's National Hospital  Washington District of Columbia USA"},{"name":"Division of Blood Banking and Transfusion Medicine Children's National Hospital  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9699-2216","authenticated-orcid":false,"given":"YoungNa","family":"Lee\u2010Kim","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Pediatrics Baylor College of Medicine Texas Children's Cancer and Hematology Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Sartain","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Pediatrics Baylor College of Medicine Texas Children's Cancer and Hematology Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6819-4049","authenticated-orcid":false,"given":"Clay T.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Pediatrics Baylor College of Medicine Texas Children's Cancer and Hematology Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2009.12.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0741\u20105214(97)70064\u20108"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001794"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239\u2010014\u20101106\u20101"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.12.061"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2021.08.035"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00260"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.04.025"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11\u20102308"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538\u20107836.2005.01204.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15144"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.76.3.F163"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951119003093"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018024786"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630\u2010015\u20100500\u20102"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24899"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100038\u20101642635"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001860"}],"container-title":["Pediatric Blood &amp; 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