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We demonstrate a proof of concept for pediatric surgeons treating young adults with pulmonary metastatic sarcomas. Five successful fluorescence\u2010guided pulmonary metastasectomy operations were performed in young adult patients with metastatic osteosarcoma or Ewing sarcoma following administration of pafolacianine. All osteosarcoma lesions identified using standard techniques were also markedly fluorescent in patients. Novel fluorescent molecular agents targeted to tumor\u2010specific receptors have promise of increased sensitivity and specificity for detecting metastatic nodules and enhancing surgical clearance of disease.<\/jats:p>","DOI":"10.1002\/pbc.31293","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T06:44:25Z","timestamp":1724827465000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Let it glow: Intraoperative visualization of pulmonary metastases using pafolacianine, a next\u2010generation fluorescent agent, for young adults undergoing pulmonary metastasectomy"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3046-4108","authenticated-orcid":false,"given":"Alison","family":"Lehane","sequence":"first","affiliation":[{"name":"Northwestern Quality Improvement, Research &amp; Education in Surgery (NQUIRES) Northwestern University Feinberg School of Medicine  Chicago Illinois USA"},{"name":"Division of Pediatric Surgery Department of Surgery Ann &amp; Robert H. 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Lurie Children's Hospital of Chicago Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.5858\/2008-132-1079-PAMLTI"},{"issue":"1","key":"e_1_2_9_3_1","first-page":"6","article-title":"Pulmonary metastasectomy in pediatric solid tumors","volume":"6","author":"Croteau NJ","year":"2019","journal-title":"Children (Basel)"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2020.10.013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30317-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70665-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2023.05.011"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2022.12.016"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/15533506221088401"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2020.3003"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1343"},{"key":"e_1_2_9_12_1","unstructured":"Abramson Cancer Center at Penn Medicine.A pilot single dose open\u2010label study of OTL38 injection (OTL38) for intra\u2010operative imaging of folate receptor positive ovarian cancer. 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