{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T20:20:11Z","timestamp":1776111611504,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T00:00:00Z","timestamp":1728172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and aim<\/jats:title><jats:p>The survival outcomes of pediatric patients with mature B\u2010non\u2010Hodgkin lymphoma (NHL) have improved due to advances in treatment. We aimed to assess the frequency and severity of late effects and their impact on quality of life among pediatric NHL survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>This retrospective study included patients diagnosed with mature B\u2010NHL at Children's Cancer Hospital of Egypt (CCHE) 57357 from January 2012 through December 2015. Patients received treatment according to the modified LMB 96 protocol. The minimum follow\u2010up period was 5\u00a0years. Assessments for toxicity and quality of life were conducted at regular intervals during and after treatment. Patients were assessed for toxicity including pulmonary dysfunction, cardiac dysfunction, lipid profile abnormalities, endocrine dysfunction (thyroid function, vitamin D levels, growth curves), and cognitive function (intelligence quotient [IQ] level using Stanford\u2013Binet Intelligence Scales\u20145th Edition, and quality of life (QoL) assessment (PedsQoL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 273 patients were eligible, and 206 were evaluable. Median age was 5.45 (range: 2.4\u201318), with a male\u2010to\u2010female ratio 4:1. Pulmonary function abnormalities were detected in 119\/203 (58.6%); most had mild dysfunction (72\/119, 60.5%), while 17% had severe dysfunction. Cardiac toxicity occurred in 10% of the patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a020). IQ testing showed that 52 patients had a low average IQ score, while 151 patients had either average or above average scores. The total mean QoL score was 99\u00a0\u00b1\u00a00.058 classified as \u201csatisfactory.\u201d However, significant impairment of the physical domain of quality of life was observed among group C patients compared to A\/B (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.033), older age at diagnosis (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.042), and those with pulmonary dysfunction (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Total score of quality of life was significantly impaired among patients with pulmonary dysfunction (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.009), likewise older age at diagnosis (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.017) and those with low average IQ scores (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.033).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Childhood mature B\u2010NHL survivors are at significant risk for late effects; pulmonary dysfunction and low average IQ that can subsequently impact QoL<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31357","type":"journal-article","created":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T03:53:36Z","timestamp":1728273216000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Quality of life and late therapy effects in pediatric non\u2010Hodgkin lymphoma survivors: Insights from a single\u2010institution study"],"prefix":"10.1002","volume":"71","author":[{"given":"Azza","family":"Ayad","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology Cancer Children's Hospital of Egypt 57357  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reham","family":"Khedr","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology Cancer Children's Hospital of Egypt 57357  Cairo Egypt"},{"name":"Department of Pediatric Hematology\/Oncology National Cancer Institute  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa","family":"Hamoda","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology Cancer Children's Hospital of Egypt 57357  Cairo Egypt"},{"name":"Department of Pediatric Hematology\/Oncology National Cancer Institute  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahla","family":"Elnabarawy","sequence":"additional","affiliation":[{"name":"Department of Cancer Survivorship Cancer Children's Hospital of Egypt 57357  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elhamy","family":"Rifky","sequence":"additional","affiliation":[{"name":"Department of Cancer Survivorship Cancer Children's Hospital of Egypt 57357  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamer","family":"Diab","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology Cancer Children's Hospital of Egypt 57357  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman El","family":"Desouky","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics National Cancer Institute  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology, Stem Cell Transplantation Dana\u2010Farber Cancer Institute, Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa","family":"Elhaddad","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology Cancer Children's Hospital of Egypt 57357  Cairo Egypt"},{"name":"Department of Pediatric Hematology\/Oncology National Cancer Institute  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,6]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"National Cancer Institute.National Childhood Cancer Registry: NCCR*Explorer: an interactive website for NCCR cancer statistics.National Cancer Institute. 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