{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T16:26:52Z","timestamp":1792772812017,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thrombocytopenia is a common hematologic finding in children and adolescents. Immune thrombocytopenia (ITP) is the most common cause of this finding, but the differential diagnosis includes a growing list of genetic disorders. We aimed to report differences in phenotypes of patients with ITP, inherited platelet disorder (IPD)\/primary immunodeficiency disorder (PID), and other causes, with a focus on differentiating ITP from inherited thrombocytopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>This retrospective, population\u2010based observational cohort from 2006 to 2020 involved 506 Finnish children under 16\u00a0years of age presenting with isolated thrombocytopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 506 participants, 79.7% had ITP, 6.7% had IPD\/PID, and 13.6% had other causes of thrombocytopenia. A platelet count of \u226412 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L best distinguished between ITP and other reasons with a sensitivity of 60% and a specificity of 80%. Among patients with the lowest platelet count of less than 10 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L, 95.9% had ITP, 3.3% had IPD\/PID, and 0.8% had other causes. Severe bleeding events were reported in 20 patients (4.0%), but there were no cases of intracranial or fatal bleeding due to thrombocytopenia. Up to 50% of patients with a high suspicion of inherited thrombocytopenia remained without a specific diagnosis despite genetic testing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      ITP remains the most common cause of thrombocytopenia. A platelet count of \u226412 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L often leads to an ITP diagnosis. Genetic disorders are rare but should be suspected in patients with persisting thrombocytopenia, especially with platelet counts constantly above 12 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L, a positive family history, or atypical clinical features.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.31363","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T01:18:52Z","timestamp":1728091132000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Immune or inherited thrombocytopenia? A population\u2010based cohort study on children and adolescents presenting with a low platelet count"],"prefix":"10.1002","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6546-2236","authenticated-orcid":false,"given":"Lauri\u2010Matti","family":"Kulmala","sequence":"first","affiliation":[{"name":"Research Unit of Clinical Medicine University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2025-3676","authenticated-orcid":false,"given":"Henri","family":"Aarnivala","sequence":"additional","affiliation":[{"name":"Research Unit of Clinical Medicine University of Oulu  Oulu Finland"},{"name":"Department of Children and Adolescents Oulu University Hospital  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tytti","family":"Pokka","sequence":"additional","affiliation":[{"name":"Research Service Unit Oulu University Hospital  Oulu 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