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Three patients were started on belzutifan due to vision loss from progressive retinal hemangioblastomas. Within one\u00a0year of treatment, all three patients had improvement in hemangioblastoma size and visual acuity. For patients with intracranial lesions, belzutifan resulted in an improvement in neurologic symptoms and hemangioblastoma size. Four patients experienced grade 1\u20132 anemia and two patients required a dose reduction. Our report suggests that belzutifan can be an effective therapy for pediatric, adolescent, and young adult patients with VHL\u2010associated hemangioblastomas.<\/jats:p>","DOI":"10.1002\/pbc.31371","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T04:29:15Z","timestamp":1729139355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pediatric patients with von Hippel\u2013Lindau and hemangioblastomas treated successfully with belzutifan"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0277-6067","authenticated-orcid":false,"given":"Emily","family":"Duan","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of California Los Angeles (UCLA)  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Robinson","sequence":"additional","affiliation":[{"name":"Division of 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