{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:10:32Z","timestamp":1790179832009,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Vomiting is a common and distressing acute side effect of chemotherapy, negatively impacting quality of life, nutritional status, and the ability of patients to tolerate further treatment. Standardized guidelines have been developed to improve control of nausea and vomiting. We aimed to determine the benefit of adherence to clinical practice guidelines (CPGs) on complete control of acute chemotherapy\u2010induced vomiting in newly diagnosed pediatric patients with cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An electronic dashboard of pediatric patients newly diagnosed with cancer at Phoenix Children's Hospital between August 2019 and January 2021 and receiving their first cycle of chemotherapy was utilized to monitor chemotherapy regimen, antiemetic medications, and vomiting episodes. Blocks were classified as guideline\u2010inconsistent, guideline\u2010consistent, or guideline\u2010consistent PLUS if additional prophylactic antiemetic medications were utilized. We identified patients with complete control of vomiting, defined as no vomiting and no additional antiemetics needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 136 patients, 29% received guideline\u2010inconsistent care, 37% received guideline\u2010consistent care, and 34% received guideline\u2010consistent PLUS care. Overall, 48% of patients achieved complete control of vomiting. Older patients (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001) and those receiving higher emetogenicity chemotherapy (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.0003) were more likely to receive guideline\u2010consistent or guideline\u2010consistent PLUS therapy. With guideline\u2010consistent and \u2010consistent PLUS grouped together, the diagnosis was also associated with improved adherence to CPGs (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.022). Multivariate analysis showed that patients more likely to receive guideline\u2010consistent prophylaxis were of older age (OR 1.11, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.016) and solid tumor patients (OR 5.59, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.028).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite high rates of CPG adherence, complete control of vomiting remains suboptimal, which highlights the need for novel and\/or risk\u2010adapted therapies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31372","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T04:24:43Z","timestamp":1729139083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Vomiting despite adherence to guidelines: Suboptimal control of vomiting in pediatric cancer patients"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7088-4193","authenticated-orcid":false,"given":"Rotem Fishel","family":"Ben\u2010Kenan","sequence":"first","affiliation":[{"name":"Center for Cancer and Blood Disorders Phoenix Children's Hospital  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily K.","family":"Stafford","sequence":"additional","affiliation":[{"name":"University of Arizona College of Medicine\u2010Phoenix  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M'hamed","family":"Temkit","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Phoenix Children's Hospital  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9204-1559","authenticated-orcid":false,"given":"Jamie","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Phoenix Children's Hospital  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6261-8357","authenticated-orcid":false,"given":"Alexandra","family":"Walsh","sequence":"additional","affiliation":[{"name":"Center for Cancer and Blood Disorders Phoenix Children's Hospital  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-020-05652-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-009-0651-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds021"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JOP.2012.000816"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27646"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3332-x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3384-y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25915"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27646"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27488"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/10781552221122026"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedn.2023.10.011"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30395"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756\u20109966\u201028\u2010131"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.06.005"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012775.pub2"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2015.12.001"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010015\u20102809\u20103"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2023.102512"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147\u2010015\u20100908\u20102"}],"container-title":["Pediatric Blood &amp; 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