{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:04:29Z","timestamp":1753869869841,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T00:00:00Z","timestamp":1729036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Auer rods (AuRs) are prominent intracellular structures found almost exclusively in myeloid cell malignancies, such as acute myeloid leukemia (AML), chronic and juvenile myelomonocytic leukemia and myelodysplastic syndrome. Extremely rare AuRs have been reported in patients with acute lymphoblastic leukemia (ALL) or among ambiguous lineage leukemia patients with a dominantly lymphoblastic immunophenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We report diagnostic and follow\u2010up data of an international cohort of 11 children suffering from leukemias with AuRs and with significant presence of T and myeloid markers, majority of whom categorized as early T\u2010cell precursor (ETP, <jats:italic>n<\/jats:italic>\u00a0=\u00a07); or T\u2010ALL (ETP status unknown, <jats:italic>n<\/jats:italic>\u00a0=\u00a02), ALAL (acute leukemia of ambiguous lineage, <jats:italic>n<\/jats:italic>\u00a0=\u00a01), and AML reclassified from ALAL (<jats:italic>n<\/jats:italic>\u00a0=\u00a01). We described other diagnostic details and treatment types and responses. Moreover, we summarize previously published data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the four patients who started and remained on ALL\u2010type therapy, all were in the first complete remission, whereas both patients who started and remained on AML\u2010type therapy relapsed and died. Of the patients who followed either a combined ALL\/AML protocol (Interfant 06) or who switched from one of the two types of therapy to the other, one patient died, and the remaining four were in first complete remission at the most recent follow\u2010up. We also searched for similar cases in the literature and found only three additional children with nonmyeloid leukemia and AuRs and 10 adults with this type of leukemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Briefly, ALL\u2010 or combined ALL\/AML\u2010type therapy may be effective for treating AuR\u2010positive leukemia patients with a lymphoid immunophenotype.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31394","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T04:25:22Z","timestamp":1729139122000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Auer rod\u2010positive acute leukemia with predominantly lymphoid immunophenotype: Report on 11 cases and review of literature"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7611-1335","authenticated-orcid":false,"given":"Ondrej","family":"Hrusak","sequence":"first","affiliation":[{"name":"CLIP Charles University  Prague Czech Republic"},{"name":"Department of Pediatric Hematology and Oncology Motol Hospital  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1059-3404","authenticated-orcid":false,"given":"Jitka","family":"Stancikova","sequence":"additional","affiliation":[{"name":"CLIP Charles University  Prague Czech Republic"},{"name":"Department of Pediatric Hematology and Oncology Motol Hospital  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Vodickova","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology Motol Hospital  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9863-2318","authenticated-orcid":false,"given":"Tereza","family":"Podolska","sequence":"additional","affiliation":[{"name":"CLIP Charles University  Prague Czech Republic"},{"name":"Department of Cell Biology, Faculty of Science Charles University  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"M\u00f6ricke","sequence":"additional","affiliation":[{"name":"Department of Paediatrics University Medical Centre Schleswig\u2010Holstein, Campus Kiel  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9285-6898","authenticated-orcid":false,"given":"Andishe","family":"Attarbaschi","sequence":"additional","affiliation":[{"name":"St. Anna Children's Cancer Research Institute (CCRI)  Vienna Austria"},{"name":"Department of Pediatrics and Adolescent Medicine St. Anna Children's Hospital, Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8175-1097","authenticated-orcid":false,"given":"Michael","family":"Dworzak","sequence":"additional","affiliation":[{"name":"St. Anna Children's Cancer Research Institute (CCRI)  Vienna Austria"},{"name":"Department of Pediatrics and Adolescent Medicine St. Anna Children's Hospital, Medical University of Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3229-0404","authenticated-orcid":false,"given":"Zuzana","family":"Sestakova","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Institute of Children's Diseases  Bratislava Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2889-2656","authenticated-orcid":false,"given":"Peter","family":"Svec","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology, National Institute of Children's Diseases Comenius University  Bratislava Slovakia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1639-7124","authenticated-orcid":false,"given":"Marketa Kubricanova","family":"Zaliova","sequence":"additional","affiliation":[{"name":"CLIP Charles University  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iveta","family":"Janotova","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Motol Hospital  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3009-7491","authenticated-orcid":false,"given":"Ondrej","family":"Zapletal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Biochemistry University Hospital and Masaryk University Brno  Brno Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5169-4653","authenticated-orcid":false,"given":"Ester","family":"Mejstrikova","sequence":"additional","affiliation":[{"name":"CLIP Charles University  Prague Czech Republic"},{"name":"Department of Pediatric Hematology and Oncology Motol Hospital  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6818-7743","authenticated-orcid":false,"given":"Jan","family":"Stary","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Motol Hospital  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.2304.404"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-190606000-00008"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21978"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(94)90281-X"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13872"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/BS9.0000000000000145"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16326"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-643544"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26392"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2014.49.3.196"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-020-03069-4"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13706"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.13084"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-369835"},{"key":"e_1_2_11_16_1","article-title":"Auer rods in mixed phenotype acute leukemia, T\/myeloid: a report of three cases","volume":"15","author":"Li Y","year":"2021","journal-title":"Leuk Res Rep"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15621"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14924"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020010470"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2009.07.005"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.htct.2021.06.018"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-002-0574-0"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2007.01023.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2019.08.003"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000205630"},{"key":"e_1_2_11_26_1","first-page":"85","article-title":"Multiple auer rods in fine\u2010needle aspiration smears of medullary thyroid carcinoma: an unusual finding","volume":"13","author":"Avval MM","year":"2020","journal-title":"Int Med Case Rep J"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-12-821363"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.21518"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cytob.21144"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.204974"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08955.x"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70314-0"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07807-0"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00263"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V124.21.1.1"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.31394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T13:21:05Z","timestamp":1739971265000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.31394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,16]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/pbc.31394"],"URL":"https:\/\/doi.org\/10.1002\/pbc.31394","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"type":"print","value":"1545-5009"},{"type":"electronic","value":"1545-5017"}],"subject":[],"published":{"date-parts":[[2024,10,16]]},"assertion":[{"value":"2024-05-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e31394"}}