{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T16:34:02Z","timestamp":1769099642904,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T00:00:00Z","timestamp":1729468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe treatments and outcomes of French children treated for relapsed\/refractory anaplastic lymphoma kinase\u2010positive anaplastic large cell lymphoma (ALK+ ALCL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted the analysis of a series of 75 French children treated for a first relapsed\/refractory ALK+ ALCL between 1999 and 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median time to first relapse was 8.1\u00a0months from initial diagnosis (2.9 after end of treatment), with 12 relapses during frontline treatment or within 1\u00a0month of the end of treatment. Treatment of the first relapse varied according to the period of time and risk factors: 48 received multiagent chemotherapy, including 21 and 19 consolidated with allogeneic stem cell transplantation (SCT) and autologous\u2010SCT, respectively. Twenty\u2010one patients received weekly vinblastine, and six received ALK inhibitors (ALKi). Overall, 64\/75 patients reached a second complete remission (CR2). Eight out of 11 patients who did not reach CR2 died and the other three were rescued with ALKi, vinblastine, and nivolumab. With a median follow\u2010up of 8.2\u00a0years, 60 patients are alive, 43 in CR2, 15 in CR3, two in CR4; and 15 patients died, six from toxicity and nine from disease progression. The 5\u2010year event\u2010free survival and overall survival after first relapse were 51.7% (95% confidence interval [CI]: 39.6%\u201362.6%) and 80.7% (95% CI: 69.6%\u201388.1%), respectively. Time to relapse greater than 12\u00a0months from initial diagnosis was proven to be a prognostic factor in relapsed\/refractory ALK+ ALCL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In relapsed ALK+ ALCL, high survival rate can be reached with various therapeutic strategies. The main challenge remains to prevent subsequent relapses, and to lower long\u2010term morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31397","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T04:05:58Z","timestamp":1729569958000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcome of childhood ALK\u2010positive anaplastic large cell lymphoma relapses: Real\u2010life experience of the French Society of Pediatric Oncology (SFCE) cohort of 75 French children"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2721-520X","authenticated-orcid":false,"given":"Victor","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Besan\u00e7on University Hospital  Besan\u00e7on France"},{"name":"Department of Pediatric and adolescents Oncology, Gustave Roussy cancer Institute Paris Saclay University  Villejuif France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u00ebl","family":"Barthoulot","sequence":"additional","affiliation":[{"name":"Department of Methodology and Biostatistics Oscar Lambret Center  Lille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0231-4460","authenticated-orcid":false,"given":"Nathalie","family":"Aladjidi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology Bordeaux University Hospital  Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Contet","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology and Hematology University Children's Hospital of Nancy  Nancy France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Hugues","family":"Dalle","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Immunology, Robert Debr\u00e9 Academic Hospital GHU AP\u2010HP Nord Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie \u00c9milie","family":"Dourthe","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Immunology, Robert Debr\u00e9 Academic Hospital GHU AP\u2010HP Nord Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Garnier","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Lyon University Hospital  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6453-6395","authenticated-orcid":false,"given":"B\u00e9n\u00e9dicte","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology Lille University Hospital  Lille 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