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Descriptive information related to (a) pregnancy history as maternal stressful life events with perceived distress during pregnancy, weight gain, alcohol and tobacco consumption, mode of delivery and gestational age; and (b) perinatal features as congenital pathologies, weight at birth and type of feeding were examined to identify potential risk factors for NB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Stressful life events during pregnancy and certain congenital pathologies were independently associated with NB risk. No significant associations were found between other features. Breastfeeding rates were similar between cases and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results underscore the importance of providing support and care to pregnant women to reduce potential stressors. Further research is needed to better understand the influence of dysbiosis and mitochondrial\u2010nuclear communication impairment as underlying mechanisms of maternal stress during pregnancy and presence of congenital pathologies in order to confirm them as potential risk factors for NB.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31402","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T09:16:30Z","timestamp":1733130990000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk of developing neuroblastoma influenced by maternal stressful life events during pregnancy and congenital pathologies"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5604-8818","authenticated-orcid":false,"given":"Nuria","family":"Benavent","sequence":"first","affiliation":[{"name":"Pathology Department Medical School University of Valencia  Valencia Spain"},{"name":"INCLIVA Biomedical Research Institute  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela","family":"Ca\u00f1ete","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Unit Hospital Universitari i Polit\u00e8cnic La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-1670","authenticated-orcid":false,"given":"Lucas","family":"Moreno","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Unit Vall d'Hebron University Hospital  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Gros","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Unit Vall d'Hebron University Hospital  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Verd\u00fa\u2010Amor\u00f3s","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Unit Hospital Cl\u00ednico Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio","family":"Salinas","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Unit Hospital Universitario Son Espases  Palma de Mallorca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Navarro","sequence":"additional","affiliation":[{"name":"Pathology Department Medical School University of Valencia  Valencia Spain"},{"name":"INCLIVA Biomedical Research Institute  Valencia Spain"},{"name":"Centro de investigaci\u00f3n biom\u00e9dica en red de c\u00e1ncer (CIBERONC)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"\u00c1lvaro","sequence":"additional","affiliation":[{"name":"Centro de investigaci\u00f3n biom\u00e9dica en red de c\u00e1ncer (CIBERONC)  Madrid Spain"},{"name":"Department of Pathology Hospital de Tortosa Verge de la Cinta  Madrid Spain"},{"name":"Institut d'Investigaci\u00f3 Sanit\u00e0ria Pere Virgili (IISPV)  Tortosa Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8449-5674","authenticated-orcid":false,"given":"Juan Antonio","family":"Carbonell\u2010Asins","sequence":"additional","affiliation":[{"name":"INCLIVA Biomedical Research Institute  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Noguera","sequence":"additional","affiliation":[{"name":"Pathology Department Medical School University of Valencia  Valencia Spain"},{"name":"INCLIVA Biomedical Research Institute  Valencia Spain"},{"name":"Centro de investigaci\u00f3n biom\u00e9dica en red de c\u00e1ncer (CIBERONC)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mop.0000150631.60571.89"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2013.09.002"},{"key":"e_1_2_10_4_1","first-page":"90","article-title":"Pre\u2010conceptional and prenatal exposure to pesticides and pediatric neuroblastoma. 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