{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:04:30Z","timestamp":1753869870405,"version":"3.41.2"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T00:00:00Z","timestamp":1729987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 3\u2010week\u2010old neonate with glucose\u20106\u2010phosphate dehydrogenase (G6PD) deficiency and primary lactic acidosis developed haemolytic jaundice and methaemoglobinaemia following treatment with dichloroacetate (DCA), a standard treatment for primary lactic acidosis. While this mechanism has been reported in the sheep model, it has not been described in humans. Our case reinforces the uncommon observation that a G6PD\u2010deficient individual experiencing oxidative stress may develop concurrent methaemoglobinaemia. In this case, methylene blue, the standard treatment for methaemoglobinaemia, may result in further oxidative stress. The judicious use of blood transfusion to correct the oxygen\u2010carrying capacity of our patient led to reversal of the methaemoglobinaemia.<\/jats:p>","DOI":"10.1002\/pbc.31408","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T04:38:57Z","timestamp":1730090337000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: Dichloroacetate\u2010induced methaemoglobinaemia in a G6PD\u2010deficient neonate"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1500-1151","authenticated-orcid":false,"given":"Ze Lei","family":"Tan","sequence":"first","affiliation":[{"name":"Khoo Teck Puat\u2014National University Children's Medical Institute National University Health System  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7948-8891","authenticated-orcid":false,"given":"Nicholas Beng Hui","family":"Ng","sequence":"additional","affiliation":[{"name":"Khoo Teck Puat\u2014National University Children's Medical Institute National University Health System  Singapore Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline Soo May","family":"Ong","sequence":"additional","affiliation":[{"name":"Khoo Teck Puat\u2014National University Children's Medical Institute National University Health System  Singapore Singapore"},{"name":"Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312\u2010021\u20102113\u2010x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0273\u20102300(84)90025\u20104"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010009\u20100952\u2010x"},{"volume-title":"Glucose\u20106\u2010Phosphate Dehydrogenase Deficiency","year":"2022","author":"Richardson SR","key":"e_1_2_8_5_1"},{"volume-title":"Methemoglobinemia","year":"2023","author":"Ludlow JT","key":"e_1_2_8_6_1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acc.2016.06.003"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/mjt.0000000000000028"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2020.05.099"},{"volume-title":"Primary Mitochondrial Disorders Overview","year":"2021","author":"Chinnery PF","key":"e_1_2_8_10_1"},{"volume-title":"POLG\u2010Related Disorders","year":"2024","author":"Cohen BH","key":"e_1_2_8_11_1"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.31408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T13:23:34Z","timestamp":1739971414000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.31408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,27]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/pbc.31408"],"URL":"https:\/\/doi.org\/10.1002\/pbc.31408","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"type":"print","value":"1545-5009"},{"type":"electronic","value":"1545-5017"}],"subject":[],"published":{"date-parts":[[2024,10,27]]},"assertion":[{"value":"2024-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e31408"}}