{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T05:00:50Z","timestamp":1754110850997,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01 CA195547","P30 CA21765"],"award-info":[{"award-number":["U01 CA195547","P30 CA21765"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adult survivors of unilateral, nonmetastatic, non\u2010syndromic Wilms tumor (WT) treated with whole abdomen radiation therapy (WART) are at risk for impaired kidney function. The impact of bias and accuracy on estimated glomerular filtration rate (eGFR) among adult survivors of WT has not been well documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We clinically evaluated male and female WT survivors with creatinine and cystatin C, calculated eGFR using the Chronic Kidney Disease\u2014Epidemiology equations with and without cystatin C, and measured <jats:sup>99m<\/jats:sup>Tc diethylenetriamine pentaacetic acid (DTPA) plasma clearance. WT survivors treated with unilateral nephrectomy (UN), non\u2010nephrotoxic chemotherapy (NNC) and WART or treated with UN, no radiation therapy, and NNC were enrolled. Correlations between <jats:sup>99m<\/jats:sup>Tc DTPA clearance and eGFR were calculated. Bias and the percentage of eGFR calculations that differed from the <jats:sup>99m<\/jats:sup>Tc DTPA clearance by 10% or less (<jats:italic>P<\/jats:italic><jats:sub>10<\/jats:sub>) or 30% or less (<jats:italic>P<\/jats:italic><jats:sub>30<\/jats:sub>) (accuracy) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among female WT survivors, none of the eGFR calculations was statistically significantly correlated with <jats:sup>99m<\/jats:sup>Tc DTPA clearance. Among both unirradiated and WART\u2010treated male WT survivors, <jats:sup>99m<\/jats:sup>Tc DTPA clearance correlated well with eGFR calculations that included creatinine. eGFR calculations that included creatinine were positively biased among female participants compared to <jats:sup>99m<\/jats:sup>Tc DTPA clearance, and no <jats:italic>P<\/jats:italic><jats:sub>30<\/jats:sub> was greater than 90% among either irradiated males or females.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among female survivors of unilateral, nonmetastatic, non\u2010syndromic WT who have undergone UN, eGFR is poorly correlated with, is positively biased, and lacks sufficient accuracy, compared to <jats:sup>99m<\/jats:sup>Tc DTPA clearance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31409","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T09:48:25Z","timestamp":1730886505000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The accuracy of estimating equations for the evaluation of kidney function in adult survivors of unilateral, nonmetastatic, non\u2010syndromic Wilms tumor: A pilot study from the St. Jude Lifetime Cohort Study"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5156-5410","authenticated-orcid":false,"given":"Daniel M.","family":"Green","sequence":"first","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingjuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics St. Jude Children's Research 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