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This work aimed to investigate the associations between pregnancy\u2010related and perinatal factors and childhood lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a pooled analysis of two French nationwide population\u2010based case\u2013control studies. Data on sociodemographic, perinatal and lifestyle factors were collected through maternal interviews. Odds ratios (OR) and 95% confidence intervals (CIs) were computed using adjusted logistic regression models, separately for non\u2010Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). Specific analyses also investigated Burkitt NHL and nodular sclerosis HL, two most common histological types in children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 305 NHL, 328 HL and 2415 controls in this study. No associations were observed with gestational age, foetal growth indicators, folic acid supplementation, factors related to maternal fertility and reproductive history, or maternal smoking during pregnancy. Maternal coffee consumption during pregnancy was associated with NHL (&gt;2\u00a0cups\/day, OR = 1.5 [95% CI: 1.1\u20132.1]), with a dose\u2013response relationship; while maternal alcohol consumption was associated with Burkitt NHL (OR = 1.5 [1.1\u20132.2]). Paternal smoking during preconception\/pregnancy was associated with NHL (OR = 1.4 [1.1\u20131.8]). Breastfeeding (ever\/never) was not significantly associated with NHL and HL, but an inverse log\u2010linear trend was observed with the duration of breastfeeding for NHL (<jats:italic>p<\/jats:italic> = 0.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal coffee and alcohol consumptions during pregnancy and paternal smoking during preconception\/pregnancy might increase the risk of childhood NHL. While warranting replication, these findings could help us better understand the aetiology of childhood lymphoma.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31439","type":"journal-article","created":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T13:44:47Z","timestamp":1732369487000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association Between Perinatal Factors and Childhood Lymphoma\u2014A Pooled Analysis of the ESCALE and ESTELLE Studies (SFCE)"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8071-7006","authenticated-orcid":false,"given":"Elissa","family":"Msallem","sequence":"first","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Inserm, INRAE Center for Research in Epidemiology and StatisticS (CRESS), Epidemiology of Childhood And Adolescent Cancer (EPICEA) team  Paris 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