{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:26:11Z","timestamp":1787761571350,"version":"build-2784847793"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006058","name":"St. Baldrick's Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006058","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>ACCL0431 was a randomized clinical trial that demonstrated efficacy of sodium thiosulfate (STS) for preventing cisplatin\u2010induced hearing loss (CIHL) among patients 1\u201318\u00a0years old. The purpose of this study was to evaluate possible differential STS otoprotection among patient subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>This secondary analysis included ACCL0431 participants treated with cisplatin and randomized to receive STS or not (observation). Hearing status was obtained at 4\u00a0weeks and 12\u00a0months post cisplatin therapy (SIOP Ototoxicity Scale). Cumulative incidence of CIHL (Grade 1+) was assessed across age, sex, race\/ethnicity, cancer diagnosis, and cisplatin infusion duration. Associations between these variables and CIHL were assessed using multivariable logistic regression. Interaction terms were used to evaluate potential heterogeneity in STS effect sizes across subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among evaluable participants (\n                      <jats:italic>n<\/jats:italic>\n                      = 121), CIHL incidence was 22.4% with STS and 54.0% with observation. Odds of developing CIHL were greatest among children less than 5\u00a0years versus older (randomization\u2010adjusted odds ratio [OR] 2.94, 95% CI: 1.30\u20137.14) and those with neuroblastoma, hepatoblastoma, or medulloblastoma versus germ cell tumor or osteosarcoma (age\u2010 and randomization\u2010adjusted OR 11.26, 95% CI: 3.08\u201347.35). STS otoprotective effect sizes were also greatest in the same highest risk groups by age (&lt;5\u00a0years: OR 0.08, 95% CI: 0.02\u20130.32; \u22655\u00a0years: OR 0.39, 95% CI: 0.15\u20131.06) and cancer diagnosis (neuroblastoma\/hepatoblastoma\/medulloblastoma: OR 0.1, 95% CI: 0.02\u20130.45; germ cell tumor\/osteosarcoma: OR 0.32, 95% CI: 0.06\u20131.25). Significant otoprotection from STS was noted across other subgroups with varied magnitudes of effect.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>STS otoprotection appears to differ across clinically meaningful subgroups, particularly age at diagnosis. These results inform clinical decision\u2010making and future research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.31479","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T23:28:03Z","timestamp":1733786883000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Otoprotective Effects of Sodium Thiosulfate by Demographic and Clinical Characteristics: A Report From Children's Oncology Group Study ACCL0431"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1098-2330","authenticated-orcid":false,"given":"Timothy J. D.","family":"Ohlsen","sequence":"first","affiliation":[{"name":"Cancer and Blood Disorders Center Seattle Children's Hospital University of Washington  Seattle Washington USA"},{"name":"Ben Towne Center for Childhood Cancer Research Seattle Children's Research Institute  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem H.","family":"Collier","sequence":"additional","affiliation":[{"name":"Department of Population and Public Health Sciences Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagadeesh","family":"Ramdas","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology\/Oncology Geisinger Medical Center  Danville Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian","family":"Sung","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5280-990X","authenticated-orcid":false,"given":"David R.","family":"Freyer","sequence":"additional","affiliation":[{"name":"Cancer and Blood Disease Institute Children's Hospital Los Angeles  Los Angeles California USA"},{"name":"Departments of Pediatrics Medicine, and Population and Public Health Sciences Keck School of Medicine University of Southern California  Los Angeles California 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