{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:27:28Z","timestamp":1787761648337,"version":"build-2784847793"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01 CA195547"],"award-info":[{"award-number":["U01 CA195547"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA21765"],"award-info":[{"award-number":["P30 CA21765"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The relationships among treatment exposures, body composition, and estimated glomerular filtration rate (eGFR) in adult survivors of Wilms tumor have not been well studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We evaluated body composition with dual\u2010energy x\u2010ray absorptiometry (DXA) and eGFR with the updated Chronic Kidney Disease Epidemiology Collaboration equations (creatinine only\u2014eGFR\n                      <jats:sub>Cr<\/jats:sub>\n                      , cystatin C only\u2014eGFR\n                      <jats:sub>CysC<\/jats:sub>\n                      , creatinine and cystatin C\u2014eGFR\n                      <jats:sub>Cr+CysC<\/jats:sub>\n                      ) without race in 134 adults previously treated for unilateral, non\u2010syndromic Wilms tumor at St. Jude Children's Research Hospital between 1964 and 2004 with chemotherapy and with (hemiabdomen [HA] or whole abdomen [WA]) or without radiation therapy (RT).\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores for DXA variables were calculated using data from the National Health and Nutrition Examination Survey.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      WART was associated with a lower relative total (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004) and trunk (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) lean mass, eGFR\n                      <jats:sub>Cr<\/jats:sub>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.008), eGFR\n                      <jats:sub>CysC,<\/jats:sub>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), and eGFR\n                      <jats:sub>Cr+CysC<\/jats:sub>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), and higher values of cystatin C (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Linear regression demonstrated that relative total lean mass (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.009) and relative trunk lean mass (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001)\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores, and eGFR\n                      <jats:sub>Cr<\/jats:sub>\n                      (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.013) were lower among those who received WART compared to No RT patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      WART is associated with lower relative total and trunk lean mass\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores and eGFR, regardless of the equation used, and is lower in survivors treated with WART compared to unirradiated survivors of unilateral, non\u2010syndromic WT. Assessments using other GFR measures may provide greater insight into the mechanism and magnitude of kidney function loss among WART\u2010treated WT survivors.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pbc.31485","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T01:54:46Z","timestamp":1734486886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Kidney Function and Body Composition in Adult Survivors of Unilateral, Non\u2010Syndromic Wilms Tumor: A Report From the St. Jude Lifetime Cohort Study"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5156-5410","authenticated-orcid":false,"given":"Daniel M.","family":"Green","sequence":"first","affiliation":[{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee 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