{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:27:17Z","timestamp":1787761637892,"version":"build-2784847793"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp;amp; Cancer"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Programs allowing access to investigational drugs and off\u2010label drug use for serious diseases have often been applied to pediatric cancers. A clinical study conducted under the Japanese \u201cPatient\u2010Proposed Healthcare Services\u201d evaluated the efficacy and safety of dabrafenib plus trametinib in children with\n                    <jats:italic>BRAF<\/jats:italic>\n                    V600 mutant glioma (jRCTs071210071). This study successfully provided unapproved and off\u2010label medications to four enrolled patients, two with low\u2010grade glioma and two with high\u2010grade glioma (median age: 10.5\u00a0years), until regulatory approval. The timeframe and data collection from such access programs need to be optimized for pediatric patients in accordance with the healthcare system of each nation.\n                  <\/jats:p>","DOI":"10.1002\/pbc.31510","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T23:18:36Z","timestamp":1736205516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Access Program for Unapproved and Off\u2010Label Drug Use in Pediatric\n                    <i>BRAF<\/i>\n                    V600E\u2010Mutated Brain Tumors in Japan"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7470-499X","authenticated-orcid":false,"given":"Maya","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Pediatrics. 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