{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T20:03:41Z","timestamp":1774901021743,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Sickle cell anemia has a genetic origin characterized by an autosomal recessive inheritance pattern. The nervous system may be subject to vaso\u2010occlusion and, consequently, affect the proper functioning of the central portion of hearing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess central auditory skills and analyze short\u2010 and long\u2010latency auditory evoked potentials in children with sickle cell disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional study. All children had normal hearing thresholds, and their central auditory processing underwent behavioral assessment with a battery of tests involving dichotic and monotic listening, binaural interaction, and temporal processing. The electrophysiological assessment used short\u2010 and long\u2010latency auditory evoked potentials. Descriptive statistics were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 28 subjects evaluated (mean age of 9.46\u00a0years), 18 were females and 10 were males. Central auditory processing disorder was identified in 85.7% of the children. The auditory skills of figure\u2010ground for verbal sounds, binaural interaction, and complex temporal ordering were the most affected. An increase in the absolute latencies of Waves III and V was observed in the short\u2010latency potential.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Individuals with sickle cell disease have central auditory processing disorder, identified primarily by behavioral assessment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31539","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T03:55:31Z","timestamp":1736913331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Behavioral and Electrophysiological Assessment of Central Auditory Processing in Individuals With Sickle Cell Disease"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6383-1838","authenticated-orcid":false,"given":"Rhayane Vit\u00f3ria","family":"Lopes","sequence":"first","affiliation":[{"name":"Department of Audiology and Speech Therapy Universidade Federal de S\u00e3o Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7839-6904","authenticated-orcid":false,"given":"Josefina Aparecida Pellegrini","family":"Braga","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Universidade Federal de S\u00e3o Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4745-0418","authenticated-orcid":false,"given":"Andrea","family":"Angel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Universidade Federal de S\u00e3o Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8647-6813","authenticated-orcid":false,"given":"Daniela","family":"Gil","sequence":"additional","affiliation":[{"name":"Department of Audiology and Speech Therapy Universidade Federal de S\u00e3o Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"3008","article-title":"General Aspects of the Neonatal Screening in Brazil: A Review","volume":"30","author":"Mendes I. C.","year":"2020","journal-title":"Revista Medica De Minas Gerais"},{"key":"e_1_2_11_3_1","unstructured":"A. M. G.Alves M. C. A.Queiroz M. T.Arruda andP. I. CAra\u00fajo \u201cDoen\u00e7a Falciforme: Conhecer para Cuidar. Minist\u00e9rio da Sa\u00fade\u2010Secretaria de Vigil\u00e2ncia em Sa\u00fade \u201d published online2015 https:\/\/www.gov.br\/saude\/pt\u2010br."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-84842007000300003"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-84842007000300009"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2019.04.032"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-127740"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1808-86942012000100020"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000492171"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.13307"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2018.10.042"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/14992020903321742"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215106001678"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198804000-00005"},{"key":"e_1_2_11_15_1","unstructured":"American Speech\u2010Language\u2010Hearing Association \u201cCentral Auditory Processing Disorders\u2014The Role of the Audiologist [Position Statement] \u201dASHA published2005 accessed May 30 2024 http:\/\/www.asha.org\/policy."},{"key":"e_1_2_11_16_1","unstructured":"British Society of Audiology \u201cPosition Statement and Practice Guidance Auditory Processing Disorder (APD) \u201dBritish Society of Audiology 2018 www.thebsa.org."},{"key":"e_1_2_11_17_1","unstructured":"Conselho Federal de Fonoaudiologia \u201cAvalia\u00e7\u00e3o e Interven\u00e7\u00e3o no Processamento Auditivo central: Guia de orienta\u00e7\u00e3o \u201dBras\u00edlia: Conselho Federal de Fonoaudiologia;2020 https:\/\/www.fonoaudiologia.org.br\/wp\u2010content\/uploads\/2020\/10\/CFFa_Guia_Orientacao_Avaliacao_Intervencao_PAC.pdf."},{"key":"e_1_2_11_18_1","unstructured":"\u201cRecomenda\u00e7\u00f5es e Valores de Refer\u00eancia para o Protocolo de Avalia\u00e7\u00e3o do PAC: Comportamental e Eletrofisiol\u00f3gica. 31o F\u00f3rum: Diagn\u00f3stico Audiol\u00f3gico \u201dEncontro Internacional de Audiologia published online2016."},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.9771\/cmbio.v13i3.12942"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30193-9"},{"key":"e_1_2_11_21_1","unstructured":"\u201cDiagnosis Treatment and Management of Children and Adults with Central Auditory Processing Disorder \u201dAmerican Academy of Audiology 2010 https:\/\/www.audiology.org."},{"key":"e_1_2_11_22_1","first-page":"291","volume-title":"Handbook of Central Auditory Processing Disorder","author":"Baran Jane A.","year":"2014"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3766\/jaaa.16.8.4"},{"key":"e_1_2_11_24_1","first-page":"276","volume-title":"Arquivos Internacionais de Otorrinolaringologia","author":"Becker K. T.","year":"2011"},{"key":"e_1_2_11_25_1","first-page":"369","volume-title":"Handbook of Central Auditory Processing Disorder","author":"Weihing J.","year":"2014"},{"key":"e_1_2_11_26_1","unstructured":"G. D.ChermakandF. EMusiek \u201cCentral Auditory Processing Disorders: New Perspectives \u201dASHA published online1997."},{"issue":"3","key":"e_1_2_11_27_1","first-page":"20","article-title":"Central Auditory Processing Disorders: Review and Case Study","volume":"28","author":"Palfery T. D.","year":"2007","journal-title":"Axone"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2012\/11-0352)"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acn.2005.06.012"},{"key":"e_1_2_11_30_1","volume-title":"Late Potentials of the Auditory System","author":"McPherson D. L.","year":"1996"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.31539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T06:17:59Z","timestamp":1741760279000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.31539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,14]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/pbc.31539"],"URL":"https:\/\/doi.org\/10.1002\/pbc.31539","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,14]]},"assertion":[{"value":"2024-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e31539"}}