{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:04:42Z","timestamp":1753869882892,"version":"3.41.2"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pediatric abdominal rhabdomyosarcoma (RMS) represents an oncosurgical challenge. For adults with peritoneal carcinomatosis and for children\/adolescents with desmoplastic small round cell tumors (DSRCT), cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) has been shown to be an effective treatment. Thereby, we present the largest series on CRS and HIPEC in patients with abdominal RMS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Between August 2013 and January 2024, 18 patients (9 female and 9 male) with abdominal RMS underwent CRS and HIPEC at our institution. All patients were treated according to an institutionalized protocol. The indication for surgery was established by a multidisciplinary national tumor board. HIPEC was performed using cisplatin (37.5\u2013100\u00a0mg\/m<jats:sup>2<\/jats:sup>) and doxorubicin (15\u201330\u00a0mg\/m<jats:sup>2<\/jats:sup>) for 60\u00a0min at 42\u00b0C. A retrospective review of patient's records was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age at operation was 3.8 years. A complete cytoreduction was achieved in 17\/18 patients. Median length of hospital stay was 11 days. Mean length of ICU stay was 2.5 days. No procedure\u2010associated complications and no major short\u2010\/long\u2010term toxicities were recorded. The median follow\u2010up was 20 months. The 5\u2010year overall survival (OS) and event\u2010free survival (EFS) were 72% and 53%, respectively. Patients &gt;10 years and those with alveolar histology had the worst prognosis (OS 0%). Patients with relapse after HIPEC (6\/18) had a significantly poorer survival compared with those without recurrence (OS 33% vs. 100%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CRS and HIPEC are effective in patients with abdominal RMS. Patients &gt;10 years, those with alveolar RMS and those with relapse after HIPEC had the worst outcome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31573","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T04:49:25Z","timestamp":1738730965000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Pediatric Abdominal Rhabdomyosarcoma: Experience of a Reference Pediatric Oncosurgical Center"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8909-0484","authenticated-orcid":false,"given":"Cristian","family":"Urla","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery and Pediatric Urology University Children's Hospital of Tuebingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Pediatric Urology University Children's Hospital of Tuebingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9775-0403","authenticated-orcid":false,"given":"Andreas","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Pediatric Urology University Children's Hospital of Tuebingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Fideler","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University Hospital of Tuebingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology University Hospital of Tuebingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Neunhoeffer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Pulmonology and Pediatric Intensive Care Medicine University Children's Hospital of Tuebingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4229-8058","authenticated-orcid":false,"given":"Martin","family":"Ebinger","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology University Children's Hospital of Tuebingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Seitz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Urology University Hospital Giessen\/Marburg  Marburg Germany"},{"name":"Department of Pediatric Surgery University Hospital Giessen\/Marburg  Giessen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery and Pediatric Urology University Children's Hospital of Tuebingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,4]]},"reference":[{"issue":"8","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1002\/cncr.11285","article-title":"Role of Surgery for Nonmetastatic Abdominal Rhabdomyosarcomas: A Report From the Italian and German Soft Tissue Cooperative Groups Studies","volume":"97","author":"Cecchetto G.","year":"2003","journal-title":"Cancer: Interdisciplinary International Journal of the American Cancer 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Y.","year":"2001","journal-title":"Hepato\u2010Gastroenterology"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052985"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2006.03.079"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b16844"},{"issue":"1","key":"e_1_2_9_14_1","first-page":"45","article-title":"Chemotherapy for Intraperitoneal Use: A Review of Hyperthermic Intraperitoneal Chemotherapy and Early Post\u2010Operative Intraperitoneal Chemotherapy","volume":"7","author":"Goodman M. D.","year":"2016","journal-title":"Journal of Gastrointestinal Oncology"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20012"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.12.2382"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2023.07.002"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.31573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T06:19:40Z","timestamp":1741760380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.31573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,4]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/pbc.31573"],"URL":"https:\/\/doi.org\/10.1002\/pbc.31573","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"type":"print","value":"1545-5009"},{"type":"electronic","value":"1545-5017"}],"subject":[],"published":{"date-parts":[[2025,2,4]]},"assertion":[{"value":"2024-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e31573"}}