{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:05:25Z","timestamp":1771034725304,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Paediatric relapse\/refractory T\u2010cell acute lymphoblastic leukaemia (T\u2010ALL) is notoriously difficult to treat. This group of heavily pre\u2010treated patients needs effective agents that can rapidly control the disease while not having significant toxicity. Homoharringtonine (HHT) has been widely used in children with acute myeloid leukaemia, but there is little information on T\u2010ALL. In this case series, HHT, in combination with other agents, achieved good response in five paediatric patients with T\u2010ALL. The in vitro drug profiling in one patient demonstrated clinical correlation with HHT activity. The study sheds light on the potential of precision medicine for patients with relapsed\/refractory leukaemia.<\/jats:p>","DOI":"10.1002\/pbc.31576","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T12:49:38Z","timestamp":1738154978000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Homoharringtonine in Relapsed\/Refractory Paediatric T\u2010Cell Acute Lymphoblastic Leukaemia\u2014A Case Series and a Report on the Use of In Vitro Drug Profiling"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7941-0211","authenticated-orcid":false,"given":"Pui Yung Grace","family":"Tong","sequence":"first","affiliation":[{"name":"Hong Kong Children's Hospital  Kowloon Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanglan","family":"Lin","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong Prince of Wales Hospital  Shatin Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kam Tong","family":"Leung","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong Prince of Wales Hospital  Shatin Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofan","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology &amp; Blood Disease Hospital Chinese Academy of Medical College, Tianjin Institutes of Health Science  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology &amp; Blood Disease Hospital Chinese Academy of Medical College, Tianjin Institutes of Health Science  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingliao","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology &amp; Blood Disease Hospital Chinese Academy of Medical College, Tianjin Institutes of Health Science  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2810-5758","authenticated-orcid":false,"given":"Chi Kong","family":"Li","sequence":"additional","affiliation":[{"name":"Hong Kong Children's Hospital  Kowloon Hong Kong SAR China"},{"name":"The Chinese University of Hong Kong Prince of Wales Hospital  Shatin Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01286"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375\u2010024\u201002166\u20101"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD.2019004043"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.00088"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2013.03.017"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2013\u20100077"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp\u201023\u2010536"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.02836"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102022\u2010169679"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102022\u2010165941"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010019\u201003902\u20109"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164\u2010023\u201000384\u20104"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medj.2024.07.018"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102022\u2010164933"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201002112\u20107"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/08880018.2020.1820649"}],"container-title":["Pediatric Blood &amp; Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pbc.31576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T06:19:58Z","timestamp":1741760398000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pbc.31576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,29]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/pbc.31576"],"URL":"https:\/\/doi.org\/10.1002\/pbc.31576","archive":["Portico"],"relation":{},"ISSN":["1545-5009","1545-5017"],"issn-type":[{"value":"1545-5009","type":"print"},{"value":"1545-5017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,29]]},"assertion":[{"value":"2024-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e31576"}}