{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:30:25Z","timestamp":1781530225880,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Blood &amp; Cancer"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Pediatric salivary gland malignancies (SGM) present challenges in managing cervical nodes. We aimed to characterize lymph node invasion to inform decisions regarding the need of systematic wide lymph node dissection (WLND).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>International retrospective study, conducted across seven large French and American pediatric centers, including pediatric patients (0\u201318 years) diagnosed with SGM from 2000 to 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 82 patients (median age 13 years), the parotid gland was frequently affected (60 cases). Histotypes comprised mucoepidermoid (mucoepidermoid carcinoma [MEC], 43 cases), acinic cells (acinic cells carcinoma [AcCC], 22 cases), adenoid cystic (adenoid cystic carcinoma [AdCC], 8 cases), (MASC, 6 cases), and adenocarcinoma (3 cases). Primary treatments were surgery (82 cases) and radiotherapy (20 cases; median dosage 64 gray). Cervical nodes therapy included WLND (\u22652 levels, 29 cases), limited nodes resection (LNR; one level, 13 cases), and\/or irradiation (4 cases; median 54 gray; range 52.0\u201363.0). At diagnosis, six patients had cervical node invasion (CNI) managed with LNR (four cases), WLND (two cases), and radiotherapy (three cases). After a median follow\u2010up of 6 years (range 1\u201322), nine patients had tumor event: local (four cases), cervical relapse\/progression (three cases) or combined (two cases). Of the nine with CNI, at diagnosis or relapse, four had MASC. Five\u2010year event\u2010free and overall survival (OS) rates were, respectively, 90.1% and 98.8%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CNI is rare in pediatric SGM but noted in 11% of cases, with higher incidence in MASC. Overall, outcome in SGM is good with a tailored locoregional multidisciplinary approach. Systematic lymph node dissection should be reconsidered.<\/jats:p><\/jats:sec><jats:sec><jats:title>SUMMARY<\/jats:title><jats:p>This international multi\u2010institutional study analyzed the clinical presentation and the cervical pattern of relapse of 82 pediatric patients with newly diagnosed salivary gland malignancies. Overall, nodal invasion was rare at diagnosis and only noted in 7%. In addition, 6% developed nodal relapse during follow\u2010up. Incidence of nodal spread was frequent in mammary analogue secretory carcinoma (MASC). The overall outcome was promising with a tailored locoregional multidisciplinary approach. Systematic lymph node dissection should be reconsidered in pediatric salivary gland tumors.<\/jats:p><\/jats:sec>","DOI":"10.1002\/pbc.31581","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T09:33:53Z","timestamp":1738575233000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cervical Lymph Node Invasion in Pediatric Salivary Gland Malignancies: Clinical Overview and Therapeutic Implications"],"prefix":"10.1002","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0001-7879","authenticated-orcid":false,"given":"Celine","family":"Richard","sequence":"first","affiliation":[{"name":"Department of Otolaryngology University of Tennessee Health Science Center College of Medicine  Memphis Tennessee USA"},{"name":"Division of Pediatric Otolaryngology Le Bonheur Children's Hospital  Memphis Tennessee USA"},{"name":"Division of Pediatric Otolaryngology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Carton","sequence":"additional","affiliation":[{"name":"Biostatistics, Clinical Research and Epidemiology Unit, Institut Curie  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inbal","family":"Hazkani","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Division of Pediatric Otolaryngology\u2010Head and Neck Surgery Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Couloigner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Otolaryngology Necker\u2010Enfants\u2010Malades Hospital Paris\u2010Descartes University, AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Sheyn","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology University of Tennessee Health Science Center College of Medicine  Memphis Tennessee USA"},{"name":"Division of Pediatric Otolaryngology Le Bonheur Children's Hospital  Memphis Tennessee USA"},{"name":"Division of Pediatric Otolaryngology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Rastatter","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Division of Pediatric Otolaryngology\u2010Head and Neck Surgery Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Haroun","sequence":"additional","affiliation":[{"name":"Data Departement Institut Curie  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7059-5869","authenticated-orcid":false,"given":"Sara","family":"Helmig","sequence":"additional","affiliation":[{"name":"Solid Tumor Division Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Beth","family":"Houston","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Helfre","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Institut Curie  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Thebault","sequence":"additional","affiliation":[{"name":"Department of Tumor Pediatrics Centre Oscar Lambret  Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6786-4968","authenticated-orcid":false,"given":"Nicolas","family":"Andre","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology H\u00f4pital de La Timone, AP\u2010HM  Marseille France"},{"name":"UMR INSERM 1068, CNRS UMR 7258, Aix Marseille Universit\u00e9 U105 Marseille Cancer Research Center (CRCM)  Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4717-4943","authenticated-orcid":false,"given":"Cecile","family":"Faure Conter","sequence":"additional","affiliation":[{"name":"Institut d'Hemato\u2010Oncologie Pediatrique  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natacha","family":"Teissier","sequence":"additional","affiliation":[{"name":"Pediatric Otorhinolaryngology Department Robert Debre University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7603-7828","authenticated-orcid":false,"given":"Brice","family":"Fresneau","sequence":"additional","affiliation":[{"name":"Gustave Roussy, Department of Children and Adolescent Oncology Paris\u2010Saclay University, Paris\u2010Sud University CESP, INSERM  Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2520-139X","authenticated-orcid":false,"given":"Daniel","family":"Orbach","sequence":"additional","affiliation":[{"name":"SIREDO Oncology Center (Care, Innovation and Research for Children Adolescents and Young Adults With Cancer) Institut Curie, PSL University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"key":"e_1_2_10_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21629"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30928"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.12.026"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.12.007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2022.100602"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.7.720"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20637"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23914"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2008.02.004"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010014\u20103681\u2010y"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcped.2023.100129"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24997"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.30003"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28993"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29058"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2013.04.034"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol30070456"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26204"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12911\u2010021\u201001534\u20106"},{"key":"e_1_2_10_20_1","unstructured":"TNM Classification of Malignant Tumours 8th edition | UICC. 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